First long-term evidence of neurological improvement after stem cell treatment in previously incurable spinal injuries

Neural stem cell transplantation successfully improved neurological function in patients with chronic spinal cord injuries. This groundbreaking study demonstrates the first durable evidence that stem cells can help repair devastating spinal damage.

The five-year clinical trial found two of four patients with chronic spinal injuries experienced lasting neurological improvements after stem cell treatment. Key improvements included increased motor and sensory function, enhanced muscle activity, and reduced pain levels. Most significantly, these improvements appeared within six months and remained stable for years.

For the millions worldwide suffering from spinal cord injuries, these findings establish a new treatment pathway. The treatment’s safety and durability over five years supports advancement to larger trials, potentially transforming what were once considered permanent injuries.

Reference

Martin JR, Cleary D, Abraham ME, et al. Long-term clinical and safety outcomes from a single-site phase 1 study of neural stem cell transplantation for chronic thoracic spinal cord injury. Cell Rep Med. 2024. DOI: 10.1016/j.xcrm.2024.101841