Maria Del Mar Rodriguez-Berrios, ND Abstract This article reviews how early-life microbial exposures, antibiotic use, birth mode, and diet shape gut microbiome diversity and immune homeostasis across the lifespan. It summarizes mechanisms linking dysbiosis to barrier...
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Table of Contents | 2018
Leaky Gut: Is There a Test for That?
Alisun Bonville, ND Docere Leaky gut, ie, increased intestinal permeability, is a term that gets a lot of attention on health blogs and advertisements these days. Many Americans are curious about increased intestinal permeability and believe it to be a contributing...
Biofilms: What Have We Learned from the Research?
Paul S. Anderson, NMD Docere The medical relevance of biofilms in human illness is better understood now than ever before. A simple PubMed search using the terms “biofilm” and “human” yields 14 417 publications – an indication of the breadth and depth of research on...
Archived Case Studies and Featured Content
Is Heart Failure with Reduced Ejection Fraction Reversible? A Case-Based, Integrative Approach
S.A Decker Weiss, NMD, FASA, PLC A complex ischemic cardiomyopathy case exploring myocardial recovery through guideline-directed medical therapy, device support, metabolic optimization, and experimental regenerative adjuncts. Abstract This case report examines...
Strive Compounding Pharmacy Files Federal Antitrust Lawsuit Against Eli Lilly and Novo Nordisk
ARCADIA TALLMAN Strive Compounding Pharmacy has filed a federal antitrust lawsuit against Eli Lilly and Novo Nordisk, alleging a coordinated effort to suppress competition and restrict patient access to lawful compounded GLP-1 medications. The complaint, filed on...
The First Health Food Store in America Was Opened by a Naturopathic Doctor in 1896
In 1896, a 24-year-old German immigrant named Benedict Lust opened a small store in New York City. He called it a “Kneipp store,” named after Father Sebastian Kneipp, the German priest whose water cure treatments had saved Lust’s life after conventional doctors gave...
Three Endocrine Axes Share One Energy Budget for Stress Resilience
Three Endocrine Axes Share One Energy Budget for Stress Resilience Mitochondrial reserve capacity constrains the HPA, thyroid, and gonadal systems simultaneously, determining whether stress responses stay adaptive or consolidate into chronic dysfunction. When a...
Optimizing Metabolic Health for Women: A Troubleshooting Approach to Insulin Resistance
Lara Briden, ND Insulin resistance goes far beyond blood sugar—affecting hormones, cardiovascular health, and long-term disease risk. An individualized, root-cause approach can restore metabolic flexibility and resilience in women. Abstract This article explores...
We were just early
Razi Ann Berry, Publisher 47% of our readers are MDs and DOs. Why are conventional doctors reading a naturopathic journal? When we started Applied Natural Medicine in 2005 ( then NDNR), our audience was almost entirely naturopathic physicians. Twenty years...
Restorative Formulations Introduces Microbiome Synergy: An Innovative Probiotic and Postbiotic Formula to Support Gut and Immune Health
MONTPELIER, VT – October 10, 2025 – Restorative Formulations, a physician-exclusive nutraceutical company known for its clinically effective, potent organic formulations, is proud to announce the launch of Microbiome Synergy, a potent, broad-spectrum probiotic and...
Biliary Hyperkinesia in Functional RUQ Pain: A Naturopathic Case Study
Lisa Jung, ND, FABNG Abstract Biliary hyperkinesia is an emerging functional gallbladder disorder characterized by elevated gallbladder ejection fraction and right upper quadrant pain in the absence of gallstones. This case study follows a 32-year-old woman with...
Klebsiella Dysbiosis and Ankylosing Spondylitis: A Naturopathic Case Study
Exploring the gut–joint connection in a patient with ankylosing spondylitis, highlighting the role of Klebsiella overgrowth, naturopathic interventions, and sustained clinical remission. Jennifer Cornell, ND Abstract Ankylosing spondylitis (AS) is a chronic...
Chronic Clostridioides difficile Infections: Two Naturopathic Case Studies
Jillian Finker, ND Exploring two complex cases of recurrent C. difficile infections unresponsive to antibiotics and FMT, and how naturopathic interventions supported long-term remission and restored quality of life. Abstract: Clostridoides difficile infection or CDI...
Interpreting the Unusual: Functional Insights from Atypical Breath Test Patterns
Dr. Bradley Bush, ND Unlock hidden patterns in hydrogen and methane testing—learn how atypical breath test results reveal valuable functional insights for gut health and individualized treatment strategies. Abstract Breath testing is a cornerstone diagnostic tool for...
Myasthenia Gravis and the Intestinal Microbiome: Naturopathic Translation into Clinical Practice
Jacob Schor, ND, FABNO Emerging research links gut dysbiosis and low butyrate production to myasthenia gravis. This article explores how naturopathic medicine can translate these findings into safe, patient-centered interventions. Abstract Emerging research suggests...
Functional Fermentation: Naturopathic Treatment of Entamoeba histolytica
Lauren Geyman, ND This case highlights how a naturopathic protocol—combining antiparasitic botanicals, targeted probiotics, and fermented foods—successfully eradicated Entamoeba histolytica while restoring gut balance and reducing inflammation. Abstract: Infection...
The Gut–Brain Axis: How the Nervous System Shapes Gut Health
Maura Henninger, ND Understanding the gut–brain connection reveals how stress, the autonomic nervous system, and the microbiome shape digestion, immunity, and emotional well-being—and how naturopathic care can restore balance. Abstract The gut–brain axis is a dynamic...
Chronic Clostridioides difficile Infections: Two Naturopathic Case Studies
Jillian Finker, ND Exploring two complex cases of recurrent C. difficile infections unresponsive to antibiotics and FMT, and how naturopathic interventions supported long-term remission and restored quality of life. Abstract: Clostridoides difficile infection or CDI...
Interpreting the Unusual: Functional Insights from Atypical Breath Test Patterns
Dr. Bradley Bush, ND Unlock hidden patterns in hydrogen and methane testing—learn how atypical breath test results reveal valuable functional insights for gut health and individualized treatment strategies. Abstract Breath testing is a cornerstone diagnostic tool for...
Myasthenia Gravis and the Intestinal Microbiome: Naturopathic Translation into Clinical Practice
Jacob Schor, ND, FABNO Emerging research links gut dysbiosis and low butyrate production to myasthenia gravis. This article explores how naturopathic medicine can translate these findings into safe, patient-centered interventions. Abstract Emerging research suggests...
Functional Fermentation: Naturopathic Treatment of Entamoeba histolytica
Lauren Geyman, ND This case highlights how a naturopathic protocol—combining antiparasitic botanicals, targeted probiotics, and fermented foods—successfully eradicated Entamoeba histolytica while restoring gut balance and reducing inflammation. Abstract: Infection...
Akkermansia muciniphila: Clinical Insights on a Next-Generation Probiotic
Sara Love, ND A clinician’s guide to when—and when not—to use A. muciniphila: evidence for gut-barrier support, metabolic and immune effects, pasteurized vs live formulations, and patient selection. Abstract Akkermansia muciniphila is an emerging “next-generation”...
Early MASH Reversal: Mediterranean Diet and Naturopathic Co-Management
Anna Kolomitseva, ND A 51-year-old woman with severe steatosis and minimal fibrosis achieved early liver and metabolic improvements through a Mediterranean-style diet, low-impact activity, sleep support, and adjunctive nutraceuticals co-managed with conventional...
The Gut–Brain Axis: How the Nervous System Shapes Gut Health
Maura Henninger, ND Understanding the gut–brain connection reveals how stress, the autonomic nervous system, and the microbiome shape digestion, immunity, and emotional well-being—and how naturopathic care can restore balance. Abstract The gut–brain axis is a dynamic...
The Silent Toll: How Celiac Disease Drives Psychiatric and Neurological Disorders
Christine Bowen, ND, FABNG Abstract Celiac disease (CD) is increasingly recognized as a systemic autoimmune condition whose psychiatric and neurological manifestations often precede or overshadow gastrointestinal symptoms. Evidence demonstrates strong associations...
Clinical Commentary: Climate Change, Tick-borne Illness, and the Shifting Landscape of Clinical Practice
Lynn Klassen, ND Carolyn Mukai, ND Rising temperatures and changing habitats are driving the spread of Lyme disease and co-infections into new regions—challenging outdated risk maps, diagnostic tools, and clinical assumptions. Abstract Climate change is expanding the...
Restoring Cellular Integrity: Phospholipid Therapy as a Key Treatment of Refractory Tick-Borne Disease
Melanie Stein, ND A clinical case highlights how intravenous phosphatidylcholine and targeted membrane repair strategies supported lasting recovery in a patient with refractory Lyme and co-infections. Abstract This case describes a 47-year-old female high school...
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Featured News
Restorative Formulations Introduces Microbiome Synergy: An Innovative Probiotic and Postbiotic Formula to Support Gut and Immune Health
MONTPELIER, VT – October 10, 2025 – Restorative Formulations, a physician-exclusive nutraceutical company known for its clinically effective, potent organic formulations, is proud to announce the launch of Microbiome Synergy, a potent, broad-spectrum probiotic and...
Naturopathic Doctor Continues Walk Across USA for Health Equity
Fargo, ND - Dennis Godby, 69, ND, MA, a Sacramento, CA-Licensed Naturopathic Doctor (ND), to raise awareness across the USA of significant health disparities, and support the “Health Equity,” movement, will continue his inspiring 756 mile walking trek across America...
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