Razi Ann Berry, Publisher 47% of our readers are MDs and DOs. Why are conventional doctors reading a naturopathic journal? When we started Applied Natural Medicine in 2005 ( then NDNR), our audience was almost entirely naturopathic physicians. Twenty years...
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Trending Case Studies
Restorative Formulations Introduces Microbiome Synergy: An Innovative Probiotic and Postbiotic Formula to Support Gut and Immune Health
MONTPELIER, VT – October 10, 2025 – Restorative Formulations, a physician-exclusive nutraceutical company known for its clinically effective, potent organic formulations, is proud to announce the launch of Microbiome Synergy, a potent, broad-spectrum probiotic and...
Biliary Hyperkinesia in Functional RUQ Pain: A Naturopathic Case Study
Lisa Jung, ND, FABNG Abstract Biliary hyperkinesia is an emerging functional gallbladder disorder characterized by elevated gallbladder ejection fraction and right upper quadrant pain in the absence of gallstones. This case study follows a 32-year-old woman with...
Klebsiella Dysbiosis and Ankylosing Spondylitis: A Naturopathic Case Study
Exploring the gut–joint connection in a patient with ankylosing spondylitis, highlighting the role of Klebsiella overgrowth, naturopathic interventions, and sustained clinical remission. Jennifer Cornell, ND Abstract Ankylosing spondylitis (AS) is a chronic...
Chronic Clostridioides difficile Infections: Two Naturopathic Case Studies
Jillian Finker, ND Exploring two complex cases of recurrent C. difficile infections unresponsive to antibiotics and FMT, and how naturopathic interventions supported long-term remission and restored quality of life. Abstract: Clostridoides difficile infection or CDI...
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Featured Article | 2025
Metabolite-Informed Estrogen-Pathway Modulation for Adult Female Acne Remission: A Systems-Based Case Report
Anna Kolomitseva, ND A case study illustrating how individualized hormone-metabolism targeting, dietary modulation, and circadian stabilization achieved sustained acne remission after oral-contraceptive discontinuation and brief testosterone exposure. Abstract Adult...
Case Studies | 2025
Mental Health & Insomnia – May 2025 | Volume 20 | Issue 5
Issue Details Volume 20 | Issue No.05Published: May 2025Theme: Mental Health and InsomniaISSN: 2169-1622 [simplebooklet src="https://simplebooklet.com/embed.php?wpKey=xbnZ815tnZmF3SIlTBBI6f&source=wordpress" width="100%" height="637"]
Occupationally Exacerbated Palmoplantar Dermatitis with Systemic Triggers
Carrie Phillips, ND Introduction As naturopathic physicians, we recognize that medicine is both an art and a science. It requires clinical reasoning, empirical evidence, and intuition that comes from experience. This balance is reflected in our practice, which is a...
The Integrative Management of Psoriasis
A Case Study in Homeopathy, Nutrition, and Lifestyle Medicine A comprehensive, patient-centered approach to managing psoriasis by addressing root causes through homeopathy, gut health, and metabolic balance. By Marisa Kassimir, ND Introduction and Case Presentation...
Optimizing Healthy Aging for Older Adults
Insights from a Case Series Using a Novel Supplement Regimen Jen Palmer, ND; Joseph M. Keenan, MD Dietary supplements can provide older adults a therapeutic option for maintaining optimal health without relying on prescription drugs. This article summarizes key...
From Kitty Litter to Cortical Recovery
A Naturopathic Case Study on Reversing CIRS-Induced Brain Atrophy Eric Dorninger ND, LAc This case study examines a 39-year-old male with severe neurological symptoms linked to Chronic Inflammatory Response Syndrome (CIRS) triggered by endotoxin exposure from a kitty...
From Toxicology to Clinical Application:
Applying Primary Source Research to Homeopathic Practice Jamie Oskin, ND, DTBRm, DHANP In a previous NDNR editorial, I gave a review of a groundbreaking new conference at Sonoran University in Tempe, Arizona, that was a collaborative project of the American Institute...
Therapeutic Order: Navigating an Ever-Increasing Toxic World
Healing Chronic Illness through Environmental Medicine By Kim Furtado, N.D. Exposure to heavy metals, persistent organic pollutants, and other chemicals is rising, with no clear end in sight. The identification of novel forever chemicals, contamination of everyday...
Allergies, Asthma & Eczema: Pediatric Treatment of the Atopic Triad
Autumn Frandsen, ND Abstract The atopic triad—eczema, asthma, and allergies—frequently presents early in pediatric patients and often shares overlapping immune dysfunction and environmental triggers. In this clinical review, Dr. Autumn Frandsen explores the...
Archived Case Studies and Featured Content
AHPA Leads Legislative Response to Protect Herbal Tinctures in New Hampshire
The American Herbal Products Association (AHPA) is leading a coordinated industry response to protect the sale of alcohol-based herbal tinctures and liquid extracts in New Hampshire. The issue began when a concerned AHPA member reported that the New Hampshire Liquor...
Brazilian Copper Chelation Study Puts Numbers Behind What We’ve Been Testing For
A new compound reduced hippocampal inflammation and improved memory in Alzheimer's model rats A research team in Brazil has published animal data showing a copper chelating compound can cross the blood brain barrier, pull copper out of beta amyloid plaques, and...
A Publisher’s Warning: The Pediatric Cases That Cross My Desk 20 Years Later
Razi Ann Berry, Publisher When we started publishing cases in the Journal of Applied Naturopathic Medicine (formerly NDNR), the bulk of pediatric cases were mild: ear infections, upper respiratory infections, rashes, food allergies. Parents who brought their...
Gentle
Razi Ann Berry, Publisher Why Starting Gentle Is Actually Radical The order you do things matters. When baking bread, repairing an engine, building a house; do it out of order and it fails. In medicine, we’ve reversed the order. We start with the strongest...
Sleeping Well During Dynamic Societal Change
How to Protect Sleep Health Amid Political, Economic, and Social Upheaval Catherine Darley, ND Periods of major government and societal change often trigger widespread uncertainty, leading to a rise in sleep complaints. Many clinicians are seeing this firsthand among...
Anticipatory Anxiety: A Case Study in Individualized Homeopathic Care
Michael Knapp, ND, DHANP A compelling case of chronic anxiety, compulsive behavior, and digestive distress resolved through precise homeopathic prescribing guided by pattern recognition and physical symptom correlation. Abstract A 25-year-old male with lifelong...
June 2025 Cont. References
Tauroursodeoxycholic Acid (TUDCA) And Protective Role Against Neurodegeneration Authors: Devin Miles, ND and Elizabeth Sutherland, ND Zangerolamo L, Vettorazzi JF, Rosa LRO, et al. The bile acid TUDCA and neurodegenerative disorders: An overview. Life Sci. 2021 May...
A Root-Cause Approach to Menopausal Insomnia and Brain Dysfunction: A Case Study
Discover how a 48-year-old woman overcame chronic insomnia, fatigue, and cognitive decline during menopause through a personalized, brain-first, hormone-balancing approach. Stephanie Yang, ND Abstract Menopause is not only a hormonal milestone but also a neurological...
Seeing Beyond the Mirror: How Psilocybin Could Transform Body Dysmorphic Disorder Treatment
Georgiana Cullen-Kerney, ND, LAc Emerging research reveals that psilocybin, the active compound in magic mushrooms, may offer a groundbreaking approach to treating Body Dysmorphic Disorder (BDD) by enhancing cognitive flexibility and reducing obsessive thought...
Nighttime Urination and Sleep Apnea: The Overlooked Connection
Jordan Robertson, ND Understanding the link between nocturia and obstructive sleep apnea (OSA) can improve screening and treatment outcomes, especially in women. Key Takeaways Patients with nocturia have an increased risk of obstructive sleep apnea (OSA) and may...
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Bridging the Gap: Psychedelic Medicine and the Holistic Model in Psychiatry
Suzanne Blaising, PhD, Mary Rondeau, ND Exploring how psychedelic therapy, particularly psilocybin, enhances holistic mental health care by promoting neuroplasticity, emotional breakthroughs, and sustainable recovery. Introduction: The conventional mental health care...
Flavor as Medicine: The Science of Taste is Key to Better Health
Flavors Are Neuroendocrine Signals That Direct Nutrient Intake and Body Metabolism Have you ever wondered why certain foods taste delicious during childhood or why adolescents seem drawn to bold flavors? From infancy through adolescence, our bodies are hardwired to...
Alcohol Use and Nutrient Deficiency: A Self-Reinforcing Cycle
Research shows the relationship between alcohol use and nutrient depletion is bi-directional. Chronic drinking depletes key nutrients, and pre-existing deficiencies increase vulnerability to alcohol’s effects. Alcohol use typically begins early. The average age of...
Nighttime Urination and Sleep Apnea: The Overlooked Connection
Jordan Robertson, ND Understanding the link between nocturia and obstructive sleep apnea (OSA) can improve screening and treatment outcomes, especially in women. Key Takeaways Patients with nocturia have an increased risk of obstructive sleep apnea (OSA) and may...
CE Account Registration
[pmpro_checkout]
Bridging the Gap: Psychedelic Medicine and the Holistic Model in Psychiatry
Suzanne Blaising, PhD, Mary Rondeau, ND Exploring how psychedelic therapy, particularly psilocybin, enhances holistic mental health care by promoting neuroplasticity, emotional breakthroughs, and sustainable recovery. Introduction: The conventional mental health care...
Flavor as Medicine: The Science of Taste is Key to Better Health
Flavors Are Neuroendocrine Signals That Direct Nutrient Intake and Body Metabolism Have you ever wondered why certain foods taste delicious during childhood or why adolescents seem drawn to bold flavors? From infancy through adolescence, our bodies are hardwired to...
Alcohol Use and Nutrient Deficiency: A Self-Reinforcing Cycle
Research shows the relationship between alcohol use and nutrient depletion is bi-directional. Chronic drinking depletes key nutrients, and pre-existing deficiencies increase vulnerability to alcohol’s effects. Alcohol use typically begins early. The average age of...
Depression Appears 8 Years Before Pain Begins
Study Confirms Naturopathic Understanding of Depression-Pain Connection A 21-year longitudinal study tracking over 7,300 adults has documented that depression symptoms begin rising significantly up to eight years before pain develops. Published in eClinicalMedicine by...
Resolving Acne Vulgaris Through Gut and Hormone Support: A Case Study
By Chelsea Smithback, ND Introduction Acne vulgaris is a very common skin condition, with a prevalence rate ranging from 25% to 95% among adolescents. It is more common in males than females. Acne can persist into adulthood or have a delayed onset during this stage of...
Targeting Menopausal Acne: Hormone Balancing and Skin Barrier Support in Practice
Aarti Patel, ND ABSTRACT This case study explores menopausal acne in a 55-year-old female with severe skin barrier damage from a history of using medical-grade prescription, as well as over-the-counter acne topicals, along with a more recent history of supplementing...
Mechanisms of Aging and Neurodegeneration
Exploring Thiamine Deficiency, Catecholamine Toxicity, and Angiotensin II Quinn Rivet, ND Exploring how thiamine deficiency, catecholamine-induced neurotoxicity, and Angiotensin II contribute to neurodegeneration and aging in the brain. Introduction This paper aims to...
Breaking the Cycle: Understanding PCOS-Related Skin Manifestations
Pathophysiology, Clinical Implications, and Evidence-Based Naturopathic Interventions Galina Mironova, ND Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder with systemic effects, including significant dermatologic manifestations. Acne, hirsutism,...
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Featured News
Resveratrol–Copper Combination Suppresses Glioblastoma Growth and Restores Immune Function
Tumor proliferation suppressed, immune function restored, and harmful DNA cleared with no adverse reactions reported Glioblastoma multiforme (GBM) remains among the deadliest primary brain cancers, notoriously resistant to current treatments. A 2025 pilot clinical...
Pharmacists Continue to Dispense Antidepressants Despite Hesitation, Study Finds
Pharmacists Fear Discussing Antidepressant Risks, Leaving Patients Uninformed and Overmedicated The Serotonin Theory Has Been Debunked For decades, depression treatments rested on a simple theory: low serotonin caused depression. An expansive, rigorous analysis of...









