CHRIS D. MELETIS, ND Autoimmune diseases afflict a considerable portion of the population, with recent numbers indicating that 15.9% of the US population, or 41 million people, suffer from an autoimmune...
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Table of Contents | 2021
Celiac Disease: The Importance of Adequate Management
KARLY MCMASTER, ND While the standard of care following a diagnosis of celiac disease (CD) is to prescribe a gluten-free diet (GFD), the recommended long-term management and monitoring of the condition is poorly understood. Too often, patients with CD...
Immune Response to Viruses: How Sleep/Wake Cycles Impact Clinical Outcome
TANYA LEE, ND The circadian system is a powerful regulatory system that guides the physiology of living organisms through synchronizing physiological processes to the external environment. This system of ultimate homeostatic regulation has evolved over time and...
Toxicity & Chronic Illness: Why Naturopathic Doctors Must Lead
KERI LAYTON, ND Every generation of naturopathic doctors decries the rising generation as an erosion of true naturopathy. Let me settle into my rocking chair and confess: I’m no better. While I lament the opportunity lost by older NDs who have dodged...
Multiple Sclerosis & Autoimmunity: The Impact of the Microbiome Keeps Getting Larger
MICHAËL FRIEDMAN, ND Abstract Multiple sclerosis (MS) is a chronic neuroinflammatory and demyelinating disorder increasingly linked to gut dysbiosis and immune dysregulation. Research shows that the gut microbiome shapes microglial maturation, blood–brain...
Endocannabinoids & Autoimmunity
JAKE F. FELICE, ND, LMP Autoimmune conditions and diseases of the nervous system are typically chronic, often have an early age of onset, and frequently cause significant pain, debility, and suffering. Autoimmunity is an...
Autoimmunity: The Mitochondrial Connection
CATHERINE CLINTON, ND Abstract Autoimmune diseases, now affecting over 23 million Americans, are closely linked to mitochondrial dysfunction and impaired regulatory T cell (Treg) activity. Mitochondria influence both innate and adaptive immunity, with mitochondrial...
Atopy & the Microbiome
JACLYN CHASSE-SMEATON, ND Atopic dermatitis (AD) dramatically impacts pediatric health and quality of life of the family as a whole. Although the pathogenesis of AD has not been clearly elucidated, there are multiple factors at...
EMF Exposure: Neuropsychiatric Effects
YASAMAN TASALLOTI, ND Since the start of the COVID-19 pandemic, there has been an increase in the utilization of technology to work, learn, and connect from home. To a great degree, this has been a welcomed solution in terms of convenience...
Notes from the Field: October, 2020
JARED L. ZEFF, ND, VNMI, LAC The following is not an article prepared for a medical journal. Not every statement of fact is cited or referenced. This is a commentary on the medicine, a running set of observations about practice in the field. It’s not meant to be...
Healing Through Listening- Part 2
JAMES SENSENIG, ND RICK KIRSCHNER, ND, VNMI This column is transcribed from a weekly live conversation produced by the Naturopathic Medical Institute (NMI). The goal of NMI is to preserve and promote the principles of naturopathic philosophy through...
Anxiety, Depression, and Insomnia: Treatment Using the Hippocratic Philosophy
CHRIS D. MELETIS, ND The philosophy of Hippocrates has been shown over the past 2400 years to not only have merit but also notable scientific veracity. Hippocrates advocated a natural approach to the treatment of diseases and emphasized the need for harmony...
More Than the Sum of Our Parts: The Role of Unconscious Stress in Chronic Illness
ERIN HAYFORD, ND The ultimate goal of any naturopathic medical practice is to identify and treat the cause of the illness rather than mitigate or suppress the expression – the symptoms – of disease. Through our holistic lens, we understand that...
The ECS, Cannabis, & Sleep
JAKE F. FELICE, ND, LMP Sleep is a dynamic and essential activity that involves a multitude of physiologic processes. Proper sleep assists the body with tissue repair, immune maintenance, memory storage, appetite, blood sugar control, blood...
Defeating Depression: A Holistic Approach
CHRISTINA BJORNDAL, ND SYDNEY SPEER Now, more than ever, our society is being affected by continually rising rates of mental illness. Depression is the leading cause of disability in the United States for people ages 15-44,...
Archived Case Studies and Featured Content
Increased Intracellular NAD+ Levels via Oral Supplementation With a Novel Liposomal Delivery Method: A Non-Randomized Crossover Study
Blair E, Miller A, McDonald R. Introduction: NAD+ is a critical coenzyme for cellular energy production, DNA repair, and sirtuin activity, with levels known to decline with age. While oral NAD+ supplementation is proposed for healthy aging benefits, its efficacy in...
Epstein–Barr Virus (EBV) as a Contributor to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Dr. Todd Maderis, ND Exploring immune dysregulation, viral reactivation, mitochondrial impairment, and treatment implications in post-EBV fatigue syndromes. Abstract This article examines the role of Epstein–Barr virus (EBV) reactivation and immune exhaustion in the...
Intravenous Phosphatidylcholine in Severe Refractory Mast Cell Activation Syndrome: A Case Report
Melanie Stein, ND Clinical improvement in treatment-refractory MCAS with normal conventional biomarkers and profound oral intolerance through membrane lipid therapy. This case report describes a 34-year-old woman with severe, treatment-refractory mast cell...
PANS, PANDAS, and the Expanding Landscape of Post-Infectious Neuroimmune Syndromes Across the Lifespan
Dr. Carolyn Mukai, ND, Dr. Lynn Klassen, ND, Dr. Ece Toprak, ND Expanding recognition of infection-triggered neuroinflammation in children, adolescents, and adults—and the evolving role of integrative immune regulation. Abstract: This clinical commentary...
The Current Status of Psilocybin Research: Depression, Anxiety & Trauma
By Pam Conboy Part 3 (a. & b.) of this series will provide an overview of the current status of psilocybin research in a variety of conditions. Today’s article will focus on its efficacy in depression, anxiety, and trauma. Breakthrough Therapy (2018;2019) ...
Actionable Habits That Help You Lose Weight and Stay Healthy
Simone McFarlane Achieving sustainable weight loss isn’t about dramatic diets or fleeting willpower; it’s about forming habits that support your body’s natural balance and energy. Wellness-focused changes that are consistent, manageable, and grounded in how...
Naturopathic Applications of Mild Hyperthermia
Applications in Practice John H. Furlong, ND Naturopathic medicine sits at a crossroads. As we progress through the 21st century, we have an opportunity to re-assert our unique leadership place in natural medicine. We can challenge ourselves to build on our...
Psudoscience
Razi Ann Berry, Publisher After 20 years publishing NDNR’s Applied Naturopathic Medicine journal, I've watched "dangerous pseudoscience" become the standard of care. You may remember we were called irresponsible for publishing IV nutrient protocols. Now there's...
Homeopathy
Razi Ann Berry, Publisher We started publishing homeopathic medicine cases in 2005. Many told me I would kill our credibility, that it was “pseudoscience” or that no serious medical journal would touch it. I was told I’d never attract conventional doctors as...
The Role of Histamine and Serotonin in Upper GI Motility: Clinical Insights from Three Case Reviews
Bradley Bush, ND Exploring how neuroimmune imbalances between histamine and serotonin contribute to dysmotility, GERD, and bloating—and how targeted integrative strategies can improve outcomes. Abstract This article reviews the interplay between histamine and...
FDA Removes Black Box Warnings from Hormone Replacement Therapy
New review of research shows benefits outweigh risks for women who start treatment within 10 years of menopause onset After more than two decades, the FDA is finally removing the black box warnings that have kept millions of women from accessing hormone replacement...
Micronutrient Deficiencies and Glucose Dysregulation: Clinical Implications for Insulin Resistance
Pamela Frank, BSc, ND Learn how critical micronutrients like chromium, magnesium, and zinc impact glucose metabolism, insulin sensitivity, and the prevention of chronic conditions like Type 2 diabetes. Abstract Micronutrient deficiencies play a crucial role in the...
The Integration of Naturopathic Medicine and Pharmacy: A Collaborative Approach
Emma Pollon-MacLeod, BSc., N.D. Adam Livingston, PharmD, RPh Uniting naturopathic doctors and pharmacists creates a patient-centered model that addresses chronic illness, reduces polypharmacy, and improves long-term health outcomes. This article explores how...
Metabolite-Informed Estrogen-Pathway Modulation for Adult Female Acne Remission: A Systems-Based Case Report
Anna Kolomitseva, ND A case study illustrating how individualized hormone-metabolism targeting, dietary modulation, and circadian stabilization achieved sustained acne remission after oral-contraceptive discontinuation and brief testosterone exposure. Abstract Adult...
The Role of Histamine and Serotonin in Upper GI Motility: Clinical Insights from Three Case Reviews
Bradley Bush, ND Exploring how neuroimmune imbalances between histamine and serotonin contribute to dysmotility, GERD, and bloating—and how targeted integrative strategies can improve outcomes. Abstract This article reviews the interplay between histamine and...
FDA Removes Black Box Warnings from Hormone Replacement Therapy
New review of research shows benefits outweigh risks for women who start treatment within 10 years of menopause onset After more than two decades, the FDA is finally removing the black box warnings that have kept millions of women from accessing hormone replacement...
Phytoandrogens in Pine Pollen: Emerging Evidence for Anabolic and Hormone Health
Saeid Mushtagh, ND Abstract Pine pollen Song Hua Fen (松花粉) has long been celebrated in Traditional Chinese Medicine (TCM) for its ability to nourish Yang Qi, the Heart, Lungs, resolve dampness and wind, with various attributes of health and longevity.1,2 It is now...
Clinically Proven Natural Support for Autoimmune Rheumatic Conditions
Authors: Devin Miles, ND & Elizabeth Sutherland, ND Emerging research highlights how botanicals such as berberine, cordyceps, rehmannia, and rosmarinic acid can modulate immune pathways and reduce inflammation in autoimmune diseases like lupus and rheumatoid...
Optimizing Metabolic Health for Women: A Troubleshooting Approach to Insulin Resistance
Lara Briden, ND Insulin resistance goes far beyond blood sugar—affecting hormones, cardiovascular health, and long-term disease risk. An individualized, root-cause approach can restore metabolic flexibility and resilience in women. Abstract This article explores...
Integrative Restoration of Fascia Integrity: Tabasheer and Bu Zhong Yi Qi Tang
Majid Michael Sababi, ND, DC, MS, MUAc, ABDA ABSTRACT Structural disorders such as hernias, pelvic organ prolapses, fascial laxity, and connective tissue degeneration are increasingly prevalent in modern clinical practice. While often treated surgically or...
Micronutrient Deficiencies and Glucose Dysregulation: Clinical Implications for Insulin Resistance
Pamela Frank, BSc, ND Learn how critical micronutrients like chromium, magnesium, and zinc impact glucose metabolism, insulin sensitivity, and the prevention of chronic conditions like Type 2 diabetes. Abstract Micronutrient deficiencies play a crucial role in the...
Metabolite-Informed Estrogen-Pathway Modulation for Adult Female Acne Remission: A Systems-Based Case Report
Anna Kolomitseva, ND A case study illustrating how individualized hormone-metabolism targeting, dietary modulation, and circadian stabilization achieved sustained acne remission after oral-contraceptive discontinuation and brief testosterone exposure. Abstract Adult...
The Integration of Naturopathic Medicine and Pharmacy: A Collaborative Approach
Emma Pollon-MacLeod, BSc., N.D. Adam Livingston, PharmD, RPh Uniting naturopathic doctors and pharmacists creates a patient-centered model that addresses chronic illness, reduces polypharmacy, and improves long-term health outcomes. This article explores how...
We were just early
Razi Ann Berry, Publisher 47% of our readers are MDs and DOs. Why are conventional doctors reading a naturopathic journal? When we started Applied Natural Medicine in 2005 ( then NDNR), our audience was almost entirely naturopathic physicians. Twenty years...
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Featured News
FDA Removes Black Box Warnings from Hormone Replacement Therapy
New review of research shows benefits outweigh risks for women who start treatment within 10 years of menopause onset After more than two decades, the FDA is finally removing the black box warnings that have kept millions of women from accessing hormone replacement...
Restorative Formulations Introduces Microbiome Synergy: An Innovative Probiotic and Postbiotic Formula to Support Gut and Immune Health
MONTPELIER, VT – October 10, 2025 – Restorative Formulations, a physician-exclusive nutraceutical company known for its clinically effective, potent organic formulations, is proud to announce the launch of Microbiome Synergy, a potent, broad-spectrum probiotic and...
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