SAM N. CLOUTHIER, BHSC, ND Bipolar disorder is a complex illness that affects approximately 2% of the Canadian population and affects males and females in equal numbers.1 Currently, typical treatment protocols for bipolar...
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Table of Contents | 2021
Our Bugs and Our Brains
JESSICA BRANDES, ND Abstract The human microbiome exerts profound influence on neurodevelopment, stress resilience, mood regulation, and cognitive aging. Evidence shows that early-life microbial exposures shape immune and brain maturation, while disruptions—such as...
Sceletium tortuosum: A South African Plant for Mood and Stress
JEREMY APPLETON, ND Sceletium tortuosum (aka Mesembryanthemum tortuosum) is a South African plant medicine with a centuries-long history of use. Not all Sceletium preparations are alike, owing to the presence or absence of standardization,...
Perimenopause: An Undertreated Phase in Women’s Reproductive Lives
LISA BRENT, ND, LAc Perimenopause is the time period in which women transition from premenopause (the reproductive years) into menopause. Typically, these changes occur between the ages of 40 and 51 and usually last about 4 years. Perimenopause...
The Reproductive Microbiome: Profound Implications of New Research
SARAH WYLIE, ND and JACLYN CHASSE-SMEATON, ND Once upon a time, I attended the birth of a patient in a teaching hospital in Vermont. The baby was born and crying healthfully at her mother’s breast, and it was time for the mother’s uterus to contract...
The Microbial Endocrine System
GUY CITRIN, ND I assume many of my colleagues have patients who present similarly. I myself have found that my non-serious chronically ill patients often present with similar symptoms. Clinical responses to...
Pregnenolone & Its Metabolites
CARRIE DECKER, ND When we speak of hormones, we often think of those that play a role in mediating sexual function: estrogen, testosterone, and progesterone. These hormones come from the common base molecule of cholesterol, and all 3 derive from the mother...
The ECS-Adrenal-Stress Axis
JAKE F. FELICE, ND, LMP The endocannabinoid system (ECS) responds not only to cannabis and cannabinoid molecules; it is also positively affected by diet, exercise, acupuncture, probiotics, prebiotics, acupuncture, osteopathic...
Treating Infertility: A Whole-Body Approach Including Mayan Uterine Massage & Seed Cycling
ANA LARA, NMD Fertility is a topic that many women have strong personal feelings about. I often hear my female patients say, “Having children is the one thing I am designed to do, yet I can’t get pregnant. I feel less of a...
Healthy Conception and Pregnancy: The Role of Nitric Oxide and Other Critical Factors
CHRIS D. MELETIS, ND Modern couples face many obstacles to becoming pregnant or giving birth to a healthy baby, and the distribution of contributing factors appears to be nearly equal between male and female. According to the Centers for Disease...
Healing Through Listening- Part 1
JAMES SENSENIG, ND RICK KIRSCHNER, ND, VNMI This article joins a series of articles in NDNR that are based on transcripts of the Naturopathic Medicine Institute (NMI)’s Wednesday morning call-in program, The Vital Conversation. The program is hosted by...
Notes from the Field: September, 2020
JARED L. ZEFF, ND, VNMI, LAC The following is not an article prepared for a medical journal. Not every statement of fact is cited or referenced. This is a commentary on the medicine, a running set of observations about practice in the field. It’s not meant to be...
Medicinal Mushrooms: Their Role in GI Cancers
MICHAEL TRAUB, ND, DHANP, FABNO Medicinal mushrooms play an essential role in the treatment of cancer. In the past decade, the use of mycotherapy has attracted much attention in the efforts to understand various benefits and the possible mechanisms through which...
Digestive, Skin, Immune Issues: A Complicated Case
MATTHEW STRICKLAND, ND LW, a 22-year-old female, presented to my office with a problem list that included digestive issues, skin issues, weak immune system, food/allergy sensitivities, and hormonal imbalance. LW reported that all of her health problems started at...
Vitalism as the Standard of Care- Part 2
JAMES SENSENIG, ND LETITIA DICK, ND, VNMI This article joins a series of articles in NDNR that are based on transcripts of the Naturopathic Medicine Institute (NMI)’s Wednesday morning call-in program, The Vital Conversation. The program is hosted by...
Archived Case Studies and Featured Content
From Wheelchair to Garden: Restoring Function in Complex Post-Infectious Illness Through Foundational Naturopathic Care
Dr. Jenny Tufenkian, ND A phased naturopathic approach addressing foundational digestive stabilization, EBV reactivation, neuroinflammation, and autonomic dysfunction in a severely disabled patient. Abstract Background: Myalgic encephalomyelitis/chronic fatigue...
A Case of Recurring Acute Viral Meningitis
Deborah Frances RN, ND A 14-year journey from “unexplained headaches” to confirmed HSV-2 meningitis, highlighting how accurate diagnosis, antiviral botanicals, and individualized homeopathic prescribing can control severe neurologic symptoms and cardiac...
Post-Pandemic Clinical Medicine – Addressing Long-COVID and Vaccine Injuries
An evidence-informed, dysfunction-based approach to evaluating spike protein effects, comorbidities, coagulation abnormalities, immune dysregulation, and mitochondrial dysfunction. Paul S. Anderson, NMD Abstract This clinical update summarizes a structured framework...
Resolution of Chronic Fatigue in a Patient With Post-COVID EBV Reactivation and Mold-Related Illness
Dr. Kasey Holland Hamski, ND A case illustrating the interplay between EBV reactivation, environmental mold exposure, and immune dysregulation in a patient with persistent post-viral fatigue. This case report examines chronic fatigue in a 38-year-old patient with...
Phytoandrogens in Pine Pollen: Emerging Evidence for Anabolic and Hormone Health
Saeid Mushtagh, ND Abstract Pine pollen Song Hua Fen (松花粉) has long been celebrated in Traditional Chinese Medicine (TCM) for its ability to nourish Yang Qi, the Heart, Lungs, resolve dampness and wind, with various attributes of health and longevity.1,2 It is now...
Clinically Proven Natural Support for Autoimmune Rheumatic Conditions
Authors: Devin Miles, ND & Elizabeth Sutherland, ND Emerging research highlights how botanicals such as berberine, cordyceps, rehmannia, and rosmarinic acid can modulate immune pathways and reduce inflammation in autoimmune diseases like lupus and rheumatoid...
Integrative Restoration of Fascia Integrity: Tabasheer and Bu Zhong Yi Qi Tang
Majid Michael Sababi, ND, DC, MS, MUAc, ABDA ABSTRACT Structural disorders such as hernias, pelvic organ prolapses, fascial laxity, and connective tissue degeneration are increasingly prevalent in modern clinical practice. While often treated surgically or...
Micronutrient Deficiencies and Glucose Dysregulation: Clinical Implications for Insulin Resistance
Pamela Frank, BSc, ND Learn how critical micronutrients like chromium, magnesium, and zinc impact glucose metabolism, insulin sensitivity, and the prevention of chronic conditions like Type 2 diabetes. Abstract Micronutrient deficiencies play a crucial role in the...
We were just early
Razi Ann Berry, Publisher 47% of our readers are MDs and DOs. Why are conventional doctors reading a naturopathic journal? When we started Applied Natural Medicine in 2005 ( then NDNR), our audience was almost entirely naturopathic physicians. Twenty years...
Restorative Formulations Introduces Microbiome Synergy: An Innovative Probiotic and Postbiotic Formula to Support Gut and Immune Health
MONTPELIER, VT – October 10, 2025 – Restorative Formulations, a physician-exclusive nutraceutical company known for its clinically effective, potent organic formulations, is proud to announce the launch of Microbiome Synergy, a potent, broad-spectrum probiotic and...
Biliary Hyperkinesia in Functional RUQ Pain: A Naturopathic Case Study
Lisa Jung, ND, FABNG Abstract Biliary hyperkinesia is an emerging functional gallbladder disorder characterized by elevated gallbladder ejection fraction and right upper quadrant pain in the absence of gallstones. This case study follows a 32-year-old woman with...
Klebsiella Dysbiosis and Ankylosing Spondylitis: A Naturopathic Case Study
Exploring the gut–joint connection in a patient with ankylosing spondylitis, highlighting the role of Klebsiella overgrowth, naturopathic interventions, and sustained clinical remission. Jennifer Cornell, ND Abstract Ankylosing spondylitis (AS) is a chronic...
Chronic Clostridioides difficile Infections: Two Naturopathic Case Studies
Jillian Finker, ND Exploring two complex cases of recurrent C. difficile infections unresponsive to antibiotics and FMT, and how naturopathic interventions supported long-term remission and restored quality of life. Abstract: Clostridoides difficile infection or CDI...
Interpreting the Unusual: Functional Insights from Atypical Breath Test Patterns
Dr. Bradley Bush, ND Unlock hidden patterns in hydrogen and methane testing—learn how atypical breath test results reveal valuable functional insights for gut health and individualized treatment strategies. Abstract Breath testing is a cornerstone diagnostic tool for...
Restorative Formulations Introduces Microbiome Synergy: An Innovative Probiotic and Postbiotic Formula to Support Gut and Immune Health
MONTPELIER, VT – October 10, 2025 – Restorative Formulations, a physician-exclusive nutraceutical company known for its clinically effective, potent organic formulations, is proud to announce the launch of Microbiome Synergy, a potent, broad-spectrum probiotic and...
Biliary Hyperkinesia in Functional RUQ Pain: A Naturopathic Case Study
Lisa Jung, ND, FABNG Abstract Biliary hyperkinesia is an emerging functional gallbladder disorder characterized by elevated gallbladder ejection fraction and right upper quadrant pain in the absence of gallstones. This case study follows a 32-year-old woman with...
Klebsiella Dysbiosis and Ankylosing Spondylitis: A Naturopathic Case Study
Exploring the gut–joint connection in a patient with ankylosing spondylitis, highlighting the role of Klebsiella overgrowth, naturopathic interventions, and sustained clinical remission. Jennifer Cornell, ND Abstract Ankylosing spondylitis (AS) is a chronic...
Chronic Clostridioides difficile Infections: Two Naturopathic Case Studies
Jillian Finker, ND Exploring two complex cases of recurrent C. difficile infections unresponsive to antibiotics and FMT, and how naturopathic interventions supported long-term remission and restored quality of life. Abstract: Clostridoides difficile infection or CDI...
Interpreting the Unusual: Functional Insights from Atypical Breath Test Patterns
Dr. Bradley Bush, ND Unlock hidden patterns in hydrogen and methane testing—learn how atypical breath test results reveal valuable functional insights for gut health and individualized treatment strategies. Abstract Breath testing is a cornerstone diagnostic tool for...
Myasthenia Gravis and the Intestinal Microbiome: Naturopathic Translation into Clinical Practice
Jacob Schor, ND, FABNO Emerging research links gut dysbiosis and low butyrate production to myasthenia gravis. This article explores how naturopathic medicine can translate these findings into safe, patient-centered interventions. Abstract Emerging research suggests...
The Gut–Brain Axis: How the Nervous System Shapes Gut Health
Maura Henninger, ND Understanding the gut–brain connection reveals how stress, the autonomic nervous system, and the microbiome shape digestion, immunity, and emotional well-being—and how naturopathic care can restore balance. Abstract The gut–brain axis is a dynamic...
Functional Fermentation: Naturopathic Treatment of Entamoeba histolytica
Lauren Geyman, ND This case highlights how a naturopathic protocol—combining antiparasitic botanicals, targeted probiotics, and fermented foods—successfully eradicated Entamoeba histolytica while restoring gut balance and reducing inflammation. Abstract: Infection...
Early MASH Reversal: Mediterranean Diet and Naturopathic Co-Management
Anna Kolomitseva, ND A 51-year-old woman with severe steatosis and minimal fibrosis achieved early liver and metabolic improvements through a Mediterranean-style diet, low-impact activity, sleep support, and adjunctive nutraceuticals co-managed with conventional...
The Silent Toll: How Celiac Disease Drives Psychiatric and Neurological Disorders
Christine Bowen, ND, FABNG Abstract Celiac disease (CD) is increasingly recognized as a systemic autoimmune condition whose psychiatric and neurological manifestations often precede or overshadow gastrointestinal symptoms. Evidence demonstrates strong associations...
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Naturopathic Doctor Continues Walk Across USA for Health Equity
Fargo, ND - Dennis Godby, 69, ND, MA, a Sacramento, CA-Licensed Naturopathic Doctor (ND), to raise awareness across the USA of significant health disparities, and support the “Health Equity,” movement, will continue his inspiring 756 mile walking trek across America...
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