SAM N. CLOUTHIER, BHSC, ND Bipolar disorder is a complex illness that affects approximately 2% of the Canadian population and affects males and females in equal numbers.1 Currently, typical treatment protocols for bipolar...
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Table of Contents | 2021
Our Bugs and Our Brains
JESSICA BRANDES, ND Abstract The human microbiome exerts profound influence on neurodevelopment, stress resilience, mood regulation, and cognitive aging. Evidence shows that early-life microbial exposures shape immune and brain maturation, while disruptions—such as...
Sceletium tortuosum: A South African Plant for Mood and Stress
JEREMY APPLETON, ND Sceletium tortuosum (aka Mesembryanthemum tortuosum) is a South African plant medicine with a centuries-long history of use. Not all Sceletium preparations are alike, owing to the presence or absence of standardization,...
Perimenopause: An Undertreated Phase in Women’s Reproductive Lives
LISA BRENT, ND, LAc Perimenopause is the time period in which women transition from premenopause (the reproductive years) into menopause. Typically, these changes occur between the ages of 40 and 51 and usually last about 4 years. Perimenopause...
The Reproductive Microbiome: Profound Implications of New Research
SARAH WYLIE, ND and JACLYN CHASSE-SMEATON, ND Once upon a time, I attended the birth of a patient in a teaching hospital in Vermont. The baby was born and crying healthfully at her mother’s breast, and it was time for the mother’s uterus to contract...
The Microbial Endocrine System
GUY CITRIN, ND I assume many of my colleagues have patients who present similarly. I myself have found that my non-serious chronically ill patients often present with similar symptoms. Clinical responses to...
Pregnenolone & Its Metabolites
CARRIE DECKER, ND When we speak of hormones, we often think of those that play a role in mediating sexual function: estrogen, testosterone, and progesterone. These hormones come from the common base molecule of cholesterol, and all 3 derive from the mother...
The ECS-Adrenal-Stress Axis
JAKE F. FELICE, ND, LMP The endocannabinoid system (ECS) responds not only to cannabis and cannabinoid molecules; it is also positively affected by diet, exercise, acupuncture, probiotics, prebiotics, acupuncture, osteopathic...
Treating Infertility: A Whole-Body Approach Including Mayan Uterine Massage & Seed Cycling
ANA LARA, NMD Fertility is a topic that many women have strong personal feelings about. I often hear my female patients say, “Having children is the one thing I am designed to do, yet I can’t get pregnant. I feel less of a...
Healthy Conception and Pregnancy: The Role of Nitric Oxide and Other Critical Factors
CHRIS D. MELETIS, ND Modern couples face many obstacles to becoming pregnant or giving birth to a healthy baby, and the distribution of contributing factors appears to be nearly equal between male and female. According to the Centers for Disease...
Healing Through Listening- Part 1
JAMES SENSENIG, ND RICK KIRSCHNER, ND, VNMI This article joins a series of articles in NDNR that are based on transcripts of the Naturopathic Medicine Institute (NMI)’s Wednesday morning call-in program, The Vital Conversation. The program is hosted by...
Notes from the Field: September, 2020
JARED L. ZEFF, ND, VNMI, LAC The following is not an article prepared for a medical journal. Not every statement of fact is cited or referenced. This is a commentary on the medicine, a running set of observations about practice in the field. It’s not meant to be...
Medicinal Mushrooms: Their Role in GI Cancers
MICHAEL TRAUB, ND, DHANP, FABNO Medicinal mushrooms play an essential role in the treatment of cancer. In the past decade, the use of mycotherapy has attracted much attention in the efforts to understand various benefits and the possible mechanisms through which...
Digestive, Skin, Immune Issues: A Complicated Case
MATTHEW STRICKLAND, ND LW, a 22-year-old female, presented to my office with a problem list that included digestive issues, skin issues, weak immune system, food/allergy sensitivities, and hormonal imbalance. LW reported that all of her health problems started at...
Vitalism as the Standard of Care- Part 2
JAMES SENSENIG, ND LETITIA DICK, ND, VNMI This article joins a series of articles in NDNR that are based on transcripts of the Naturopathic Medicine Institute (NMI)’s Wednesday morning call-in program, The Vital Conversation. The program is hosted by...
Archived Case Studies and Featured Content
D Laura Chan Discusses The Fertility Factor No One Talks About: Men’s Energetic Health
Emma Pollon McLeod The importance of Communication between Naturopathic Doctors and Pharmacist
Pamela Frank Micronutrient Deficiencies and Glucose Dysregulation
Lara Briden A Troubleshooting Approach to Insulin Resistance
The Silent Toll: How Celiac Disease Drives Psychiatric and Neurological Disorders
Christine Bowen, ND, FABNG Abstract Celiac disease (CD) is increasingly recognized as a systemic autoimmune condition whose psychiatric and neurological manifestations often precede or overshadow gastrointestinal symptoms. Evidence demonstrates strong associations...
Early MASH Reversal: Mediterranean Diet and Naturopathic Co-Management
Anna Kolomitseva, ND A 51-year-old woman with severe steatosis and minimal fibrosis achieved early liver and metabolic improvements through a Mediterranean-style diet, low-impact activity, sleep support, and adjunctive nutraceuticals co-managed with conventional...
Akkermansia muciniphila: Clinical Insights on a Next-Generation Probiotic
Sara Love, ND A clinician’s guide to when—and when not—to use A. muciniphila: evidence for gut-barrier support, metabolic and immune effects, pasteurized vs live formulations, and patient selection. Abstract Akkermansia muciniphila is an emerging “next-generation”...
The Gut–Brain Axis: How the Nervous System Shapes Gut Health
Maura Henninger, ND Understanding the gut–brain connection reveals how stress, the autonomic nervous system, and the microbiome shape digestion, immunity, and emotional well-being—and how naturopathic care can restore balance. Abstract The gut–brain axis is a dynamic...
Functional Fermentation: Naturopathic Treatment of Entamoeba histolytica
Lauren Geyman, ND This case highlights how a naturopathic protocol—combining antiparasitic botanicals, targeted probiotics, and fermented foods—successfully eradicated Entamoeba histolytica while restoring gut balance and reducing inflammation. Abstract: Infection...
Clinical Commentary: Climate Change, Tick-borne Illness, and the Shifting Landscape of Clinical Practice
Lynn Klassen, ND Carolyn Mukai, ND Rising temperatures and changing habitats are driving the spread of Lyme disease and co-infections into new regions—challenging outdated risk maps, diagnostic tools, and clinical assumptions. Abstract Climate change is expanding the...
Restoring Cellular Integrity: Phospholipid Therapy as a Key Treatment of Refractory Tick-Borne Disease
Melanie Stein, ND A clinical case highlights how intravenous phosphatidylcholine and targeted membrane repair strategies supported lasting recovery in a patient with refractory Lyme and co-infections. Abstract This case describes a 47-year-old female high school...
Oxaloacetate: A Missing Link in CFS, Long-Haul COVID, and Mitochondrial Performance
Chris D. Meletis, N.D. Abstract Long COVID and chronic fatigue syndrome (CFS) share overlapping pathophysiological mechanisms, with mitochondrial dysfunction emerging as a central driver of persistent fatigue, cognitive impairment, and multisystem dysregulation....
Post-Pandemic Clinical Medicine: Addressing Long-COVID and Vaccine Injuries
Post-Pandemic Clinical Medicine: Strategies for Treating Long-COVID and Vaccine-Related Injuries Paul S. Anderson, NMD A comprehensive review of definitions, pathogenesis, diagnostics, and evidence-based therapeutic approaches for managing Long-COVID and...
Unmasking Long COVID: Healing Through Immune Modulation in Adolescents
Sarah Cassidy, ND Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection, is an increasingly recognized condition affecting not only adults but also adolescents. Though often underdiagnosed in younger populations, it can present with a wide range of...
Clinical Commentary: Climate Change, Tick-borne Illness, and the Shifting Landscape of Clinical Practice
Lynn Klassen, ND Carolyn Mukai, ND Rising temperatures and changing habitats are driving the spread of Lyme disease and co-infections into new regions—challenging outdated risk maps, diagnostic tools, and clinical assumptions. Abstract Climate change is expanding the...
Restoring Cellular Integrity: Phospholipid Therapy as a Key Treatment of Refractory Tick-Borne Disease
Melanie Stein, ND A clinical case highlights how intravenous phosphatidylcholine and targeted membrane repair strategies supported lasting recovery in a patient with refractory Lyme and co-infections. Abstract This case describes a 47-year-old female high school...
Oxaloacetate: A Missing Link in CFS, Long-Haul COVID, and Mitochondrial Performance
Chris D. Meletis, N.D. Abstract Long COVID and chronic fatigue syndrome (CFS) share overlapping pathophysiological mechanisms, with mitochondrial dysfunction emerging as a central driver of persistent fatigue, cognitive impairment, and multisystem dysregulation....
Post-Pandemic Clinical Medicine: Addressing Long-COVID and Vaccine Injuries
Post-Pandemic Clinical Medicine: Strategies for Treating Long-COVID and Vaccine-Related Injuries Paul S. Anderson, NMD A comprehensive review of definitions, pathogenesis, diagnostics, and evidence-based therapeutic approaches for managing Long-COVID and...
Unmasking Long COVID: Healing Through Immune Modulation in Adolescents
Sarah Cassidy, ND Abstract Long COVID, or post-acute sequelae of SARS-CoV-2 infection, is an increasingly recognized condition affecting not only adults but also adolescents. Though often underdiagnosed in younger populations, it can present with a wide range of...
Treating Intestinal Parasites in a Lactating Woman with Classical Homeopathy: A Case Study
Miriam Wheeler, ND, DHANP (DABHM) A clinical case study demonstrating the successful eradication of Dientamoeba fragilis with Aloe socotrina in a lactating patient—offering a safe alternative to conventional antiparasitic medications. Abstract This case study details...
Polyarthralgia with Rash: A Case of Parvovirus Arthritis Mimicking Post-Streptococcal Sequelae
Prabhjot Chohan, ND, MD (India), CCRA Abstract Parvovirus B19 infection in adults can present with polyarthralgia and rash, often resembling post-streptococcal sequelae such as acute rheumatic fever or reactive arthritis. This case describes a 36-year-old female with...
The Diagnosis and Treatment of Babesiosis: A Naturopathic Approach to an Emerging Tick-Borne Disease
By Alexis Chesney, MS, ND, LAc Abstract Babesiosis is an emerging tick-borne parasitic infection in the United States caused primarily by Babesia microti and Babesia duncani. Transmitted by Ixodes ticks, babesiosis has expanded beyond its traditional strongholds in...
The Sound of Healing: Mindfulness-Based Therapy for Adolescent Mental Health
A clinical and creative exploration of how vibrational sound therapies and mindfulness practices can regulate the nervous system, reduce anxiety, and enhance emotional well-being in adolescents. Tanvi Gandhi, ND, L.Ac. Abstract Music communicates non-verbally and...
Clinical Use of Kava in Pediatric PTSD and ODD: A Case Study of Two Siblings
Michael Friedman, ND Abstract This case study explores the use of kava (Piper methysticum)and Rauwolfia vomitoria in two siblings with PTSD and ODD in an older child, and PTSD and ADHD in the younger child, following severe early-life trauma. Under naturopathic...
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Flavor as Medicine: The Science of Taste is Key to Better Health
Flavors Are Neuroendocrine Signals That Direct Nutrient Intake and Body Metabolism Have you ever wondered why certain foods taste delicious during childhood or why adolescents seem drawn to bold flavors? From infancy through adolescence, our bodies are hardwired to...
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