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Table of Contents | 2022

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Archived Case Studies and Featured Content

Air Pollution Disrupted Menstrual Cycles in Premenopausal Women

Air Pollution Disrupted Menstrual Cycles in Premenopausal Women

Common traffic and industrial exhaust gases disrupted estrogen and progesterone cycling, damaged ovarian tissue, and shortened menstrual intervals in premenopausal women, yet environmental exposure history remains absent from standard reproductive health evaluations....

Thymosin Alpha-1 Restored Immune Function Across Five Organ Systems

Thymosin Alpha-1 Restored Immune Function Across Five Organ Systems

ARCADIA TALLMAN The thymus peptide upregulated 1,198 genes tied to energy metabolism, DNA repair, and cell cycle regulation. The Thymus Shrinks With Age and Takes Immune Function With It The thymus gland loses 95% of its immature immune cells with age, and the peptide...

Fluoxetine During Development Damaged Hearing and the Brainstem

Fluoxetine During Development Damaged Hearing and the Brainstem

ARCADIA TALLMAN Fluoxetine exposure during early auditory development drove 91 gene expression changes in the brainstem, reduced the stability of mature neural circuits, and left lasting hair-cell damage in the inner ear. Fluoxetine Changed the Developing Auditory...

Sleeping Well During Dynamic Societal Change

How to Protect Sleep Health Amid Political, Economic, and Social Upheaval Catherine Darley, ND Periods of major government and societal change often trigger widespread uncertainty, leading to a rise in sleep complaints. Many clinicians are seeing this firsthand among...

June 2025 Cont. References

Tauroursodeoxycholic Acid (TUDCA) And Protective Role Against Neurodegeneration Authors: Devin Miles, ND and Elizabeth Sutherland, ND Zangerolamo L, Vettorazzi JF, Rosa LRO, et al. The bile acid TUDCA and neurodegenerative disorders: An overview. Life Sci. 2021 May...

Nighttime Urination and Sleep Apnea: The Overlooked Connection

Jordan Robertson, ND Understanding the link between nocturia and obstructive sleep apnea (OSA) can improve screening and treatment outcomes, especially in women. Key Takeaways Patients with nocturia have an increased risk of obstructive sleep apnea (OSA) and may...

Flavor as Medicine: The Science of Taste is Key to Better Health

Flavors Are Neuroendocrine Signals That Direct Nutrient Intake and Body Metabolism Have you ever wondered why certain foods taste delicious during childhood or why adolescents seem drawn to bold flavors? From infancy through adolescence, our bodies are hardwired to...

Alcohol Use and Nutrient Deficiency: A Self-Reinforcing Cycle

Research shows the relationship between alcohol use and nutrient depletion is bi-directional. Chronic drinking depletes key nutrients, and pre-existing deficiencies increase vulnerability to alcohol’s effects. Alcohol use typically begins early. The average age of...

Nighttime Urination and Sleep Apnea: The Overlooked Connection

Jordan Robertson, ND Understanding the link between nocturia and obstructive sleep apnea (OSA) can improve screening and treatment outcomes, especially in women. Key Takeaways Patients with nocturia have an increased risk of obstructive sleep apnea (OSA) and may...

Flavor as Medicine: The Science of Taste is Key to Better Health

Flavors Are Neuroendocrine Signals That Direct Nutrient Intake and Body Metabolism Have you ever wondered why certain foods taste delicious during childhood or why adolescents seem drawn to bold flavors? From infancy through adolescence, our bodies are hardwired to...

Alcohol Use and Nutrient Deficiency: A Self-Reinforcing Cycle

Research shows the relationship between alcohol use and nutrient depletion is bi-directional. Chronic drinking depletes key nutrients, and pre-existing deficiencies increase vulnerability to alcohol’s effects. Alcohol use typically begins early. The average age of...

Depression Appears 8 Years Before Pain Begins

Study Confirms Naturopathic Understanding of Depression-Pain Connection A 21-year longitudinal study tracking over 7,300 adults has documented that depression symptoms begin rising significantly up to eight years before pain develops. Published in eClinicalMedicine by...

Mechanisms of Aging and Neurodegeneration

Exploring Thiamine Deficiency, Catecholamine Toxicity, and Angiotensin II Quinn Rivet, ND Exploring how thiamine deficiency, catecholamine-induced neurotoxicity, and Angiotensin II contribute to neurodegeneration and aging in the brain. Introduction This paper aims to...

Breaking the Cycle: Understanding PCOS-Related Skin Manifestations

Pathophysiology, Clinical Implications, and Evidence-Based Naturopathic Interventions Galina Mironova, ND Polycystic Ovarian Syndrome (PCOS) is a complex endocrine disorder with systemic effects, including significant dermatologic manifestations. Acne, hirsutism,...

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