CHRIS D. MELETIS, ND KIMBERLY WILKES, BSC There is the tendency to implement identical protocols when treating women and men. However, it must be acknowledged that there are indeed gender differences. Women are more at risk of certain diseases, they...
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Table of Contents | 2021
PCOS and the Gut: The Role of the Gut Microbiome in PCOS Treatment
MICHELLE MADDUX, ND Abstract Polycystic ovary syndrome (PCOS) is a complex endocrine disorder marked by hormonal imbalance, insulin resistance, chronic inflammation, and metabolic dysfunction. In this clinical review, Dr. Michelle Maddux highlights the central...
Metformin & Myo-inositol: Management of Insulin Resistance in Women with PCOS
LIQAA ESSAM NASER, ND, MBCHB, CCT KRIS SOMOL, ND Student Scholarship – Second Place Research Review Abstract Polycystic ovary syndrome (PCOS) is a multifactorial endocrine disorder frequently characterized by insulin resistance...
Fire Proofing Materials Linked to Autism
Edited By NODE SMITH, ND From University of California, Riverside- Polybrominated diphenyl ethers, or PBDEs, are a class of fire-retardant chemicals that are ubiquitous. They are found on upholstery, carpets, curtains, electronics, and even infant products. Flame...
Getting Better Sleep Could HELP Reverse Alzheimer’s (in mice)
Edited By NODE SMITH, ND From Baylor College of Medicine- Multiple studies in humans and mouse models indicate that sleep disruptions raise the risk of Alzheimer's disease (AD) by increasing the accumulation of disease-relevant proteins such as amyloid-beta (A-beta)...
Medicare & Naturopathic Medicine: Coverage is here, in a way
DAN LABRIOLA, ND The news is good. Medicare patients have significantly greater access to naturopathic services starting this open enrollment period (October 15th to December 7th, 2021). This is likely a result of insurers responding to pressure...
Childhood Eczema & Chronic Disease: Assessing Toxin Transfer from Mom to Baby
DIANE ANGELA FONG, ND I became a naturopathic doctor because I had suffered with severe eczema since birth. As a baby, every time I breast fed, my eczema would flare up. Based on this correlation, my mother was told that I was...
Preserving Female Fertility: Key Diet and Lifestyle Factors for Maintaining Reproductive Health
Student Scholarship – First Place Research Review DAIANA CASTLEMAN, HBSC STEFANIE TROWELL, ND Women today are increasingly aware of the impact age has on their fertility. Armed with the knowledge that female fecundity begins to decrease after...
Are YOU Misunderstanding “Mindfulness”?
Edited By NODE SMITH, ND From University of Waterloo- Mindful awareness is about both accepting and engaging with life's challenges, and that's what popularized concepts of mindfulness tend to miss, new research has found. Studying popular concepts of mindfulness, the...
First Neuro Mapping of the Brain?
Edited By NODE SMITH, ND From University of California - Berkeley- When you clicked to read this story, a band of cells across the top of your brain sent signals down your spine and out to your hand to tell the muscles in your index finger to press down with just the...
A Gene that Regulates the Circadian Rhythm
Edited By NODE SMITH, ND Life is organized on a 24-hour schedule. Central to this regular rhythm is the circadian clock, timekeepers that are present in virtually every organ, tissue and cell type. When a clock goes awry, sleep disruption or a variety of diseases can...
Availability of Fast Food Leads to Types 2 Diabetes
Edited By NODE SMITH, ND From NYU Langone Health / NYU Grossman School of Medicine- An increasing number of studies suggest a link between a neighborhood’s-built environment and the likelihood that its residents will develop chronic diseases such as heart disease,...
Certain Types of Intermittent Fasting May be Beneficial for Gestational Diabetes
Edited By NODE SMITH, ND From University of South Australia- Weight loss after gestational diabetes can prevent the onset of type 2 diabetes. Yet finding the most effective way to lose weight and keep it off can be a challenge, especially for mothers with a new baby....
Skill Competency is Second in Importance to Friendliness in the Workplace
Edited By NODE SMITH, ND From Binghamton University- People who are friendly and trustworthy are more likely to be selected for teams than those who are known for just their skill competency and personal reputation, according to new research from Binghamton...
Amino Acid, Arginine, Could Enhance Radiation Therapy
Edited By NODE SMITH, ND From Weill Cornell Medicine- Treatment with arginine, one of the amino-acid building blocks of proteins, enhanced the effectiveness of radiation therapy in cancer patients with brain metastases, in a proof-of-concept, randomized clinical trial...
Archived Case Studies and Featured Content
How to Get the Most from Your Cancer Doctor Visits: A Guide for Patients and Survivors
Cancer care can be complex and overwhelming, but preparation can make medical appointments more productive and less stressful. This practical checklist offers 18 strategies to help patients communicate effectively with providers, organize their care, explore treatment options, and build a collaborative medical “dream team.”
Botanical Immunomodulation for Pancreatic Neoplasia: An Integrative Medicine Case Report
Can botanical immunomodulation play a supportive role in patients with pancreatic neoplasia? This case report describes the clinical course of a patient who declined surgery, chemotherapy, and radiation and pursued a physician-directed botanical regimen alongside nutrition, exercise, meditation, and other lifestyle measures, with subsequent imaging reportedly demonstrating stabilization followed by reduction in lesion size.
Serial ctDNA in High-Grade Serous Ovarian Carcinoma: Bridging Naturopathic and Conventional Oncology Care
Serial ctDNA testing provided an evolving molecular picture of advanced ovarian cancer, helping inform treatment decisions as the patient moved between naturopathic and conventional care. This case illustrates how multiple liquid-biopsy platforms can complement CA-125 while adding molecular detail relevant to treatment response and progression.
The Future of Precision Oncology: Molecular Profiling and Personalized Treatment in Metastatic Colorectal Cancer
How can precision oncology move beyond simply matching a mutation to a drug? Through a case of KRAS G13D metastatic colorectal cancer, this article demonstrates how serial molecular profiling can help clinicians interpret tumor evolution and integrate genomics with metabolism, nutrition, immune-directed strategies, natural medicines, repurposed pharmaceuticals, and conventional oncology.
The Missing Question: How Occupational Heavy Metal Exposure Contributed to Severe Testosterone Deficiency in a Young Male
Glenn B. Gero, ND, DSc, M.E.S., R.H. (AHG), EndoANP Kareem Kandil, MD, ND A case study demonstrating how a simple occupational history uncovered chronic heavy metal exposure as a likely contributor to severe hypogonadism, highlighting the critical role of...
Reduction of Thyroid Antibodies with Tirzepatide in Hashimoto’s Thyroiditis: A Metabolic-Immune Case Report
Dr. Valerie Gettings, NMD A case report exploring how low-dose tirzepatide improved insulin resistance, thyroid function, and thyroid autoantibody levels in a patient with Hashimoto’s thyroiditis, highlighting the emerging role of metabolic therapies in...
16-Hydroxyestrone, Enterohepatic Recirculation, and Dysmenorrhea: Personalizing Hormone Care Through Estrogen Metabolite Testing
Dr. Liz Bartman, ND A case-based exploration of how urinary estrogen metabolites can reveal hidden patterns of estrogen recirculation, gut-liver dysfunction, and hormone clearance that contribute to menstrual pain and heavy bleeding. This case report examines a...
Nigella sativa: The Ancient Herbal Remedy Supporting Thyroid Resilience in Hashimoto’s Thyroiditis
Lillea Hartwell, ND A comprehensive review of Nigella sativa seed oil, its active constituents, safety profile, pharmacology, and emerging clinical evidence for supporting immune regulation and thyroid function in Hashimoto’s thyroiditis. This monograph reviews...
When Menopausal Symptoms Aren’t Menopause: Lessons from a Case of Pituitary Hypophysitis and the Value of Comprehensive Endocrine Assessment
Adrianne M. Cook, ND, FABNE A case report illustrating how fatigue, weight gain, brain fog, metabolic dysfunction, and vasomotor symptoms initially attributed to menopause revealed underlying hypopituitarism, central adrenal insufficiency, and secondary...
Relative Energy Deficiency in Sport (RED-S): When “Eat Less, Move More” Backfires in Active Adults
Ben Alter, MA, ND How chronic low energy availability disrupts metabolism, hormones, recovery, immune function, and performance—and why recreationally active individuals may be especially vulnerable. This article explores Relative Energy Deficiency in Sport (RED-S), a...
Vitamin D Beyond Bone Health: Emerging Roles in Immunity, Metabolic Health, PMOS, and Disease Prevention
Dr. Daniella Perri, ND From widespread deficiency to VDR signaling across tissues, this review synthesizes evidence on how vitamin D shapes immunity, infection severity (including COVID-19), tumor biology, uterine fibroids, metabolic syndrome, and PMOS—and outlines...
Liver-Centered Model of Midline Adiposity & MASLD
by Majid Michael Sababi, ND, DC, MS, MUAc, ABDA Discover how hepatic steatosis, insulin resistance, and liver dysfunction contribute to visceral fat accumulation, and explore evidence-informed assessment and treatment strategies that integrate modern hepatology with...
Recurrent Pregnancy Loss Assessment: An Integrative Approach
Dr. Juline Savaya, ND Beyond “Unexplained” Recurrent Pregnancy Loss: An Integrative Approach to Immune, Hormonal, Thrombophilic, and Male-Factor Assessment Pregnancy loss occurs in approximately 15% to 20% of recognized pregnancies, though the true prevalence...
Migraines and Menopause: Two Case Studies
By Jillian Finker, ND Explore how naturopathic approaches effectively address hormonal migraines in menopausal women through real-life patient case studies. Summary: This article explores two case studies of women suffering from migraines during menopause. It...
Relative Energy Deficiency in Sport (RED-S): When “Eat Less, Move More” Backfires in Active Adults
Ben Alter, MA, ND How chronic low energy availability disrupts metabolism, hormones, recovery, immune function, and performance—and why recreationally active individuals may be especially vulnerable. This article explores Relative Energy Deficiency in Sport (RED-S), a...
Vitamin D Beyond Bone Health: Emerging Roles in Immunity, Metabolic Health, PMOS, and Disease Prevention
Dr. Daniella Perri, ND From widespread deficiency to VDR signaling across tissues, this review synthesizes evidence on how vitamin D shapes immunity, infection severity (including COVID-19), tumor biology, uterine fibroids, metabolic syndrome, and PMOS—and outlines...
Liver-Centered Model of Midline Adiposity & MASLD
by Majid Michael Sababi, ND, DC, MS, MUAc, ABDA Discover how hepatic steatosis, insulin resistance, and liver dysfunction contribute to visceral fat accumulation, and explore evidence-informed assessment and treatment strategies that integrate modern hepatology with...
Recurrent Pregnancy Loss Assessment: An Integrative Approach
Dr. Juline Savaya, ND Beyond “Unexplained” Recurrent Pregnancy Loss: An Integrative Approach to Immune, Hormonal, Thrombophilic, and Male-Factor Assessment Pregnancy loss occurs in approximately 15% to 20% of recognized pregnancies, though the true prevalence...
Migraines and Menopause: Two Case Studies
By Jillian Finker, ND Explore how naturopathic approaches effectively address hormonal migraines in menopausal women through real-life patient case studies. Summary: This article explores two case studies of women suffering from migraines during menopause. It...
Chronic Clostridioides difficile Infections: Two Naturopathic Case Studies
Exploring two complex cases of recurrent C. difficile infections unresponsive to antibiotics and FMT, and how naturopathic interventions supported long-term remission and restored quality of life. Short Description: Recurrent C. difficile infections pose a significant...
The 2026 AzureWellness Summit
Building a Community of Practitioners to Inspire Healthier Families June 22–26 Five Day Virtual Event of Education, Insight, and Whole-Person Wellness AzureWell is pleased to announce the Azure Wellness Summit, a free five-day virtual event taking place June...
The Silent Male Infertility Epidemic: How Men Can Protect & Restore Their Fertility
Dr. Samuel Madeira, N.M.D. Infertility affects about 180 million people worldwide and at least 15% of couples in the United States alone. The far-too-often overlooked factor in fertility medicine today is the male contribution, accounting for the cause of 30-50% of...
Co-Prescribing Probiotics with Antibiotics: The Case for Omni-Biotic AB 10
Omni-Biotic Human clinical trials demonstrate that functionally targeted Omni-Biotic AB 10 prevents diarrhea, reduces C. difficile risk, and eliminates multidrug resistant organism colonization in the gut. Introduction Antibiotics are among the most...
From PCOS to PMOS: What the Name Change Means for Your Practice
Dr. Jaclyn Smeaton, ND A clinical review of the landmark renaming of PCOS to PMOS and why this shift reframes the condition as a whole-body endocrine and metabolic disorder requiring broader assessment and long-term care. This article explores the recent...
Custom Publishing
Hyperbaric Oxygen Therapy in Sports Medicine: Clinical Applications in Concussion and Musculoskeletal Injury
Joseph Thomas, MD, MBA, Fellow of Metabolic and Nutritional Medicine In collaboration with Oxygen Health Systems Abstract Hyperbaric oxygen therapy has gained traction as an adjunct in sports medicine, particularly in concussion management and musculoskeletal injury....
Quantum Fields and Frequency Medicine
Quantum Fields and Frequency Medicine A Conversation with Philipp Samor von Holtzendorff Fehling on Remote Quantum Technology and Human Performance Interest in frequency medicine and subtle energy technologies continues to grow within integrative and naturopathic...
Increased Intracellular NAD+ Levels via Oral Supplementation With a Novel Liposomal Delivery Method: A Non-Randomized Crossover Study
Blair E, Miller A, McDonald R. Introduction: NAD+ is a critical coenzyme for cellular energy production, DNA repair, and sirtuin activity, with levels known to decline with age. While oral NAD+ supplementation is proposed for healthy aging benefits, its efficacy in...
Featured News
The 2026 AzureWellness Summit
Building a Community of Practitioners to Inspire Healthier Families June 22–26 Five Day Virtual Event of Education, Insight, and Whole-Person Wellness AzureWell is pleased to announce the Azure Wellness Summit, a free five-day virtual event taking place June...
NWHSU Launches New Doctor of Clinical Nutrition in Functional & Integrative Nutrition
Northwestern Health Sciences University (NWHSU) is proud to announce the launch of its new Doctor of Clinical Nutrition (DCN) in Functional and Integrative Nutrition– a practice-focused doctoral degree designed for nutrition and healthcare professionals ready to...
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