MICHELLE MADDUX, ND Abstract This article reviews the critical role of the gut microbiome in immune system development, barrier integrity, and regulation of inflammatory and autoimmune responses. It highlights mechanisms such as short-chain fatty acid...
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Table of Contents | 2021
Tick Tubes: Stopping Lyme in Its Tracks
JACOB SCHOR, ND, FABNO This past winter, my wife and I saved all the cardboard tubes at the core of toilet paper and paper towel rolls. Today (early March), I will use them to make “tick tubes.” Our nearest neighbor, a...
Wired for Self-Healing- Part 2
JAMES SENSENIG, ND LOUISE EDWARDS, ND, LAC This column is transcribed from a weekly live conversation produced by the Naturopathic Medical Institute (NMI). The goal of NMI is to preserve and promote the principles of naturopathic philosophy through...
Notes from the Field: March, 2021
JARED L. ZEFF, ND, VNMI, LAC The following is not an article prepared for a medical journal. Not every statement of fact is cited or referenced. This is a commentary on the medicine, a running set of observations about practice in the field. It’s not meant to be...
Urinary Incontinence: A Common Problem for Elderly Women
THOMAS A. KRUZEL, ND Urinary incontinence affects 23-31% of the female elderly population1 and is estimated to affect 50-65% of both sexes in hospitals and nursing homes.2 Generally, older women experience more...
Nutraceuticals for Knee OA: Naturopathic Evidence-Based Strategies
DYLAN W. KRUEGER, NMD Americans work tremendously hard for the vast majority of their lives, often with the idyllic dream of an active and exciting retirement. Unfortunately, many folks reach retirement battered, beaten, and struggling with chronic diseases and...
Dementia: Depression as a Risk Factor
ROMI FUNG, ND, MSC The “Baby Boomer” generation, defined as people born between 1946 and 1964, is a demographic cohort consisting of 76 million people around the globe born during post-World War II (WWII).1 A baby boom...
Breastfeeding & Climate Change: Can Better Policies Reduce the Crisis?
KRYSTAL PLONSKI, ND, LAC, FABNP Could better policy support of breast/chest-feeding help reduce risks of climate change? Quick answer: It could, but only when it is applied on a population-based scale. From a medical...
Pediatric ADHD: Harnessing the Superpower
TERESA NEFF, ND, CLE You may have heard people speak of attention-deficit/hyperactivity disorder (ADHD) as a superpower. Its many positive aspects, such as creativity, curiosity, hyper-focus, perseverance, and energy, can and should outweigh the...
A Toxic Start to Life: Counteracting Children’s Unique Vulnerabilities
MITCH KENNEDY, ND, LEED-AP When does the onslaught of chemicals and pollutants start for each of us? Does it start in puberty as hormones possibly upregulate receptors that could inadvertently bind toxicants rather than assist the growth and...
Epigenetics: Growing Up in a Toxic World – Part I
CHRIS D. MELETIS, ND Abstract This article explores how epigenetic influences begin shaping a child’s health long before birth—and even before conception. Dr. Chris Meletis outlines how environmental toxins, nutritional deficiencies, and lifestyle factors can...
The Cast of Characters: Combating Childhood Anxiety From a Biopsychosocial Perspective
NICOLE CAIN, ND, MA Esme is a good case example of an anxious child. Her first panic attack resulted in her losing consciousness during music class. During the second attack, she felt dizzy and nauseated, and then she missed the rest of the school...
Homeopathy in Pediatrics: A Case of Chronic Digestive Disorder
SHAHRAM AYOUBZADEH ND, MD, HOM Abstract An 11-year-old female presented with a 5-year history of chronic abdominal pain, intermittent diarrhea, nausea, and marked symptom exacerbations linked to emotional stress, particularly longstanding jealousy and resentment...
Wired for Self-Healing- Part 1
JAMES SENSENIG, ND LOUISE EDWARDS, ND, LAC This column is transcribed from a weekly live conversation produced by the Naturopathic Medical Institute (NMI). The goal of NMI is to preserve and promote the principles of naturopathic philosophy through clinical...
Promoting Planetary Health: A Necessary Part of Caring for Children
LESLIE SOLOMONIAN, BSC, ND, MPH The health of individuals is tremendously influenced by the health of their environment. This is especially true in childhood, and the effects last a lifetime. If we aim to fulfill the principles of naturopathic medicine (bolded...
Archived Case Studies and Featured Content
Post-Pandemic Clinical Medicine – Addressing Long-COVID and Vaccine Injuries
An evidence-informed, dysfunction-based approach to evaluating spike protein effects, comorbidities, coagulation abnormalities, immune dysregulation, and mitochondrial dysfunction. Paul S. Anderson, NMD Abstract This clinical update summarizes a structured framework...
Resolution of Chronic Fatigue in a Patient With Post-COVID EBV Reactivation and Mold-Related Illness
Dr. Kasey Holland Hamski, ND A case illustrating the interplay between EBV reactivation, environmental mold exposure, and immune dysregulation in a patient with persistent post-viral fatigue. This case report examines chronic fatigue in a 38-year-old patient with...
Integrative Management of Postural Orthostatic Tachycardia Syndrome (POTS) Following COVID-19: A Case-Based, Longitudinal Approach
Dr. Adelena Izold, ND A systems-based framework addressing autonomic dysfunction, gut–brain signaling, endocrine balance, and metabolic resilience in post-viral dysautonomia. This case report describes the integrative management of a 36-year-old female with post-viral...
Rebuilding the Brain in Chronic Fatigue Syndrome (CFS/ME): A Layered Naturopathic Approach to Neuroinflammation and Mitochondrial Dysfunction
A case report demonstrating sequential neurorepair, lipid repletion, microbiome stabilization, and mitochondrial support in post-infectious CFS/ME recovery. Dr. Vy Simeles, ND, Restorative Health Clinic Abstract This case report details the recovery of a 22-year-old...
The Fertility Factor No One Talks About: Men’s Energetic Health
Dr. Laura Chan, ND, L.Ac. While male fertility is usually framed around sperm quality and lifestyle, emotional suppression and energetic stagnation may play a critical role in sexual vitality, reproductive wellness, and overall health. Abstract This article explores...
Male Factor Infertility: Naturopathic Case Insights and Lifestyle-Based Interventions to Improve Sperm Health
Khivan Oberoi, ND Exploring the clinical complexities of male infertility and the impact of lifestyle, environmental, and naturopathic interventions on reproductive outcomes — with real-world case examples that demonstrate how integrative care can optimize fertility...
Mind, Immunity & Male Fertility: A Psychoneuroimmunological View of Male Reproductive Health
Dr. Nicole Cain Exploring how chronic stress, inflammation, and the gut-brain-hormone connection influence sperm quality—and how integrative, mind-body interventions can restore reproductive vitality in men. Abstract This article examines male infertility through a...
Targeting Mitochondrial Function for Upstream Steroidogenesis and Adrenal Health
Chris D. Meletis, N.D. A clinical framework for restoring adrenal and gonadal hormone balance by supporting mitochondrial bioenergetics, antioxidant capacity, and adaptogenic stress resilience—upstream of testosterone, cortisol, and thyroid therapies. Abstract This...
Recognizing Paternal Postpartum Depression: An Underaddressed Component of Perinatal Mental Health
Alexsia Priolo Understanding the signs, risk factors, screening tools, and family-wide impacts of paternal postpartum depression—and how clinicians can better support fathers throughout the perinatal period. Abstract This article highlights paternal postpartum...
The Gut-Heart-Prostate Connection: The Link between Intestinal, Cardiovascular, and Prostate Health in Men
Lina Mockus, ND Emerging research reveals that gut-derived inflammation, microbial metabolites, and metabolic dysfunction link intestinal health to cardiovascular disease and prostate disorders—highlighting key opportunities for naturopathic, lifestyle, and...
Men’s Health & Compounding: A Pharmacist’s Perspective
Dr. Fatimah Hamade, PharmD Understanding Male Hypogonadism, Hormone Balancing, and the Role of Personalized Compounding in Optimizing Testosterone Therapy Abstract This article reviews the clinical foundations of male hypogonadism, testosterone evaluation, and...
The Most EXTREME Prostate Cancer Case I Have Seen in 23 Years of Practice…and What I Learned
Phranq D. Tamburri, NMD Abstract: A rare Gleason 10 prostate cancer in an 80‑year‑old veteran with a persistently low PSA challenges conventional risk models, highlights the limits of PSA‑based screening, and illustrates how active surveillance, patient personality,...
Georgia State Brain Researchers Draw Cellular Blueprint for How We Think, Feel
A new study from experts with Georgia State University has achieved a long-standing goal in neuroscience: showing how the brain’s smallest components build the systems that shape thought, emotion and behavior, by demonstrating how specific cell types, chemical...
The Quiet Surge in Demand for Psychiatric Drug Tapering
Razi Ann Berry, Publisher We Became a Medicated Society More than one in ten American adults now take prescription medication for depression. Women receive these prescriptions at double the rate of men. Add in antipsychotics, stimulants, mood stabilizers, and...
The Gut-Heart-Prostate Connection: The Link between Intestinal, Cardiovascular, and Prostate Health in Men
Lina Mockus, ND Emerging research reveals that gut-derived inflammation, microbial metabolites, and metabolic dysfunction link intestinal health to cardiovascular disease and prostate disorders—highlighting key opportunities for naturopathic, lifestyle, and...
Men’s Health & Compounding: A Pharmacist’s Perspective
Dr. Fatimah Hamade, PharmD Understanding Male Hypogonadism, Hormone Balancing, and the Role of Personalized Compounding in Optimizing Testosterone Therapy Abstract This article reviews the clinical foundations of male hypogonadism, testosterone evaluation, and...
The Most EXTREME Prostate Cancer Case I Have Seen in 23 Years of Practice…and What I Learned
Phranq D. Tamburri, NMD Abstract: A rare Gleason 10 prostate cancer in an 80‑year‑old veteran with a persistently low PSA challenges conventional risk models, highlights the limits of PSA‑based screening, and illustrates how active surveillance, patient personality,...
Georgia State Brain Researchers Draw Cellular Blueprint for How We Think, Feel
A new study from experts with Georgia State University has achieved a long-standing goal in neuroscience: showing how the brain’s smallest components build the systems that shape thought, emotion and behavior, by demonstrating how specific cell types, chemical...
The Quiet Surge in Demand for Psychiatric Drug Tapering
Razi Ann Berry, Publisher We Became a Medicated Society More than one in ten American adults now take prescription medication for depression. Women receive these prescriptions at double the rate of men. Add in antipsychotics, stimulants, mood stabilizers, and...
Metagenics Names Patrick Sly as CEO to Lead Next Chapter of Growth
Aliso Viejo, CA – December 1, 2025 Metagenics, a leading doctor-recommended professional supplement announced it has named Patrick Sly as CEO, effective immediately. A highly regarded executive in the health and wellness industry, Mr. Sly brings a wealth of...
AHPA Leads Legislative Response to Protect Herbal Tinctures in New Hampshire
The American Herbal Products Association (AHPA) is leading a coordinated industry response to protect the sale of alcohol-based herbal tinctures and liquid extracts in New Hampshire. The issue began when a concerned AHPA member reported that the New Hampshire Liquor...
Brazilian Copper Chelation Study Puts Numbers Behind What We’ve Been Testing For
A new compound reduced hippocampal inflammation and improved memory in Alzheimer's model rats A research team in Brazil has published animal data showing a copper chelating compound can cross the blood brain barrier, pull copper out of beta amyloid plaques, and...
A Publisher’s Warning: The Pediatric Cases That Cross My Desk 20 Years Later
Razi Ann Berry, Publisher When we started publishing cases in the Journal of Applied Naturopathic Medicine (formerly NDNR), the bulk of pediatric cases were mild: ear infections, upper respiratory infections, rashes, food allergies. Parents who brought their...
Gentle
Razi Ann Berry, Publisher Why Starting Gentle Is Actually Radical The order you do things matters. When baking bread, repairing an engine, building a house; do it out of order and it fails. In medicine, we’ve reversed the order. We start with the strongest...
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Featured News
Air Pollution Disrupted Menstrual Cycles in Premenopausal Women
Common traffic and industrial exhaust gases disrupted estrogen and progesterone cycling, damaged ovarian tissue, and shortened menstrual intervals in premenopausal women, yet environmental exposure history remains absent from standard reproductive health evaluations....
Thymosin Alpha-1 Restored Immune Function Across Five Organ Systems
ARCADIA TALLMAN The thymus peptide upregulated 1,198 genes tied to energy metabolism, DNA repair, and cell cycle regulation. The Thymus Shrinks With Age and Takes Immune Function With It The thymus gland loses 95% of its immature immune cells with age, and the peptide...
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