Antibiotic-resistant Infections Are Likely Multiple Strains of Bacteria “Working Together”
Antibiotic Resistant Ecosystem Exists in Hospitals and Health Care Facilities
The newest research in the antibiotic resistant bacterial infections is starting to show that it is not isolated infections of single bacteria, but many various bacterial types that are working together.1 This is the explanation that a recent research study, looking at multidrug-resistant organisms (MDRO), has made after finding that 40 percent of elderly patients are host to multiple strains of MDRO living in their bodies. The study also looked at how groups of MDRO increase after use of a single antibiotic. The view that is being advocated is looking at bacteria as part of an antibiotic-resistant ecosystem that exists in hospitals and care facilities; that single organisms are likely not working in isolation.
Certain Pairs of MDRO More Likely to Develop Resistance
The research found that certain pairs of MDROs held a higher likelihood of developing resistant infections. The research has created a map of these interactions (between both the bacteria and the classes of antibiotics that are used to combat them). This could be crucial to the future treatment of hospital infections since it could account for the downstream effects of treatment with a single antibiotic on organisms that are resistant to it.
MDRO Colonization Appears Not to be Randomized
Colonization of patients’ skin, noses, and throats with MDROs is seemingly not random. They found a complex network of cooperation being influenced mainly by 6 MDRO species, and certain antibiotics. The primary colonization is turning into a major risk factor for the acquisition and infection by others after the primary is treated. The 6 bugs that were focused on were the most dangerous, Vancomycin-resistant Enterococcus (VRE) and methicillin-resistant Staphylococcus aureus (MRSA) as well as Proteus mirabilis, Acinetobacter baumannii, Escherichia coli and Pseudomonas aeruginosa. Proteus mirabilis is known to create a biofilm and to release urease, which serves as a means of communication among bacteria.
The article is free, and contains potentially useful visual mapping of these relationships. The link to the article can be found below.
- Wang J, Foxman B, Mody L, Snitkin ES. Network of microbial and antibiotic interactions drive colonization and infection with multidrug-resistant organisms. Proc Natl Acad Sci USA. 2017
Image Copyright: <a href=’https://www.123rf.com/profile_drmicrobe’>drmicrobe / 123RF Stock Photo</a>
Node Smith, ND, is a naturopathic physician in Portland, OR and associate editor for NDNR. He has been instrumental in maintaining a firm connection to the philosophy and heritage of naturopathic medicine among the next generation of docs. He helped found the first multi-generational experiential retreat, which brings elders, alumni, and students together for a weekend camp-out where naturopathic medicine and medical philosophy are experienced in nature. Four years ago he helped found the non-profit, Association for Naturopathic ReVitalization (ANR), for which he serves as the board chairman. ANR has a mission to inspire health practitioners to embody the naturopathic principles through experiential education. Node also has a firm belief that the next era of naturopathic medicine will see a resurgence of in-patient facilities which use fasting, earthing, hydrotherapy and homeopathy to bring people back from chronic diseases of modern living; he is involved in numerous conversations and projects to bring about this vision.