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Childhood Trauma and Mental Health: A Systems Biology Approach to Treatment-Resistant Anxiety and OCD

Childhood Trauma and Mental Health: A Systems Biology Approach to Treatment-Resistant Anxiety and OCD

Childhood adversity may leave lasting physiological effects that extend beyond psychological symptoms. Through a case of a 19-year-old woman with persistent anxiety, OCD, emotional eating, and hyperandrogenic metabolic dysfunction, this article examines how neuroendocrine, metabolic, immune, nutritional, and gut-brain pathways may interact—and how a systems biology approach can complement conventional psychiatric care.

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Observation Over Interpretation: A Homeopathic Case of Phosphorus in an 8-Month-Old

Observation Over Interpretation: A Homeopathic Case of Phosphorus in an 8-Month-Old

When an 8-month-old developed sudden distress whenever his mother left the room, the choice between Phosphorus and Pulsatilla initially appeared uncertain. Through direct observation, a previously overlooked response to physical touch became the defining symptom guiding a Phosphorus prescription, followed by reported improvement within one week.

Listening Beyond Language: A Narrative Medicine Case Study for Neurodivergent Children

Listening Beyond Language: A Narrative Medicine Case Study for Neurodivergent Children

For neurodivergent children, communication extends beyond spoken language. Through a composite pediatric case, this article explores how narrative medicine, creative expression, sensory-aware facilitation, and caregiver co-regulation can support emotional communication, self-advocacy, and connection in children with autism, ADHD, and related developmental differences.

First, Do No Harm: Managing Pediatric Klebsiella Dysbiosis Without Delaying Diagnosis

First, Do No Harm: Managing Pediatric Klebsiella Dysbiosis Without Delaying Diagnosis

A young child with recurrent abdominal pain, bloating, constipation, sleep disturbances, and behavioral changes experienced repeated symptom improvement during integrative treatment targeting intestinal dysbiosis. This case examines the challenges of managing suspected Klebsiella-associated symptoms while navigating inconsistent treatment across two households, parental hesitation toward additional testing, and the possibility of an underlying inflammatory bowel disorder.

5-MTHF and Autism: From Nonverbal to First Words in a Pediatric Case Report

5-MTHF and Autism: From Nonverbal to First Words in a Pediatric Case Report

After years of speech-language and occupational therapy without functional spoken language, an 8-year-old boy with autism began vocalizing and spontaneously spoke a meaningful word approximately two weeks after starting 5-MTHF supplementation. This case examines the temporal association, potential relevance of folate-dependent pathways, and the need for further research into communication outcomes in minimally verbal autistic children.

The “Possessed” Child: Celiac Disease, PANS/PANDAS, and the Gut-Brain Connection

The “Possessed” Child: Celiac Disease, PANS/PANDAS, and the Gut-Brain Connection

An 11-year-old boy with celiac disease experienced recurrent hallucinations, night terrors, aggression, and profound behavioral changes requiring multiple hospitalizations. This case explores the suspected relationship between infections, gastrointestinal disturbances, immune responses, and neuropsychiatric symptoms, including reported improvements following dietary modifications and microbiome-directed interventions.

From Constipation to Language Regression: A Longitudinal Case of Recurrent Behavioral and Communication Changes in an Autistic Child

From Constipation to Language Regression: A Longitudinal Case of Recurrent Behavioral and Communication Changes in an Autistic Child

In a child with autism, recurrent constipation consistently preceded episodes of behavioral dysregulation or loss of previously functional language. Through years of symptom tracking, laboratory assessment, and individualized treatment, this case explores two distinct clinical patterns potentially involving the gut-brain axis, with reported improvements following antifungal and antibacterial interventions.