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Is Heart Failure with Reduced Ejection Fraction Reversible? A Case-Based, Integrative Approach
S.A Decker Weiss, NMD, FASA, PLC A complex ischemic cardiomyopathy case exploring myocardial recovery through guideline-directed medical therapy, device support, metabolic optimization, and experimental regenerative adjuncts. Abstract This case report examines...
Strive Compounding Pharmacy Files Federal Antitrust Lawsuit Against Eli Lilly and Novo Nordisk
ARCADIA TALLMAN Strive Compounding Pharmacy has filed a federal antitrust lawsuit against Eli Lilly and Novo Nordisk, alleging a coordinated effort to suppress competition and restrict patient access to lawful compounded GLP-1 medications. The complaint, filed on...
The First Health Food Store in America Was Opened by a Naturopathic Doctor in 1896
In 1896, a 24-year-old German immigrant named Benedict Lust opened a small store in New York City. He called it a “Kneipp store,” named after Father Sebastian Kneipp, the German priest whose water cure treatments had saved Lust’s life after conventional doctors gave...
Three Endocrine Axes Share One Energy Budget for Stress Resilience
Three Endocrine Axes Share One Energy Budget for Stress Resilience Mitochondrial reserve capacity constrains the HPA, thyroid, and gonadal systems simultaneously, determining whether stress responses stay adaptive or consolidate into chronic dysfunction. When a...
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Featured Article | Pediatrics
Herbal and Functional Medicine Approach: Early Insulin Resistance in a Teenage Swimmer
Dr. Anjanaa Subramanian, MD (Natural Medicine), CFMP, MPT, PGDHM How early insulin resistance and poor dietary diversity impaired performance in a lean adolescent athlete — and how targeted herbal and functional interventions supported metabolic recovery. ABSTRACT A...
Exclusive Content | Pediatrics
Acetaminophen & NSAIDs: Re-evaluating Their Use in the Pediatric Population
Catherine Clinton, ND Docere OTC Pain and Fever Reducers Most Widely Used Drugs in Children Over-the-counter (OTC) pain and fever reducers such as ibuprofen and acetaminophen are the most widely used drugs in children.1 Regular use of these drugs is something I also...
Hardwiring the Brain: Epigenetic Modification in a Case of Childhood Rage
Nicole Cain, ND, MA Tolle Causam As many as 1,080,168 children in the United States, ages 0-5, are taking a psychiatric drug.1 If we expand the age range to 0-17, that number jumps up drastically to 8,389,034. The primary types of medications prescribed for children...
Reducing Childhood Asthma Risk
Bianca Garilli, ND Vis Medicatrix Naturae Prenatal Omega-3 Fatty Acid Supplementation The prevalence of asthma in the United States has increased from 7.3% of the population in 2001 to 8.4% in 2010. In 2010, there were an estimated 7 million children between the ages...
Oppositional Defiant Disorder: 6 Key Steps to Restoring Peace
Nicole Cain, ND Tolle Totum 6 Key Steps to Restoring Peace in Your Life & Your Child’s Life Patient story: With an engaging smile, 6-year-old Owen leaned forward on the couch and described the Millennium Falcon Lego set that he had received from his parents...
What’s All the Fuss About? A Naturopathic Approach to the Fussy Baby
Dr. Caitlin O’Connor, ND Tolle Causam Part II: In Part 1 of this article, I discussed quantifying normal infant behavior, setting families up for success using the principle of Docere. In this article, I will review interventions to consider when crying and fussing...
A Nightmare of a Case: Homeopathic Approaches to Sleep Issues in Children
Anke Zimmermann, BSc, ND, FCAH Sleep issues, including nightmares and sleep-walking, are a common problem in children. Sleep and dream symptoms are generally a clear expression of the vital force and can often lead to wonderfully accurate prescriptions that can...
The Infant Microbiome: How Environmental & Maternal Factors Influence Its Development
Carly Wendler, ND Disturbances in the establishment of the indigenous intestinal microbiome, caused by environmental and maternal factors in early life, have been linked to the risk of immune-mediated and inflammatory conditions such as atopic disorders, inflammatory...
Childhood Infections & Injuries: Topical Herbal Formulas
Jillian Stansbury, ND No one escapes childhood without some scrapes, burns, bruises, and infections. Every herbalist and family physician needs a supply of gentle but effective topical applications for lice, burns, and other common issues. Most readers will be...
Archived Case Studies and Featured Content
Epstein–Barr Virus (EBV) as a Contributor to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Dr. Todd Maderis, ND Exploring immune dysregulation, viral reactivation, mitochondrial impairment, and treatment implications in post-EBV fatigue syndromes. Abstract This article examines the role of Epstein–Barr virus (EBV) reactivation and immune exhaustion in the...
Intravenous Phosphatidylcholine in Severe Refractory Mast Cell Activation Syndrome: A Case Report
Melanie Stein, ND Clinical improvement in treatment-refractory MCAS with normal conventional biomarkers and profound oral intolerance through membrane lipid therapy. This case report describes a 34-year-old woman with severe, treatment-refractory mast cell...
PANS, PANDAS, and the Expanding Landscape of Post-Infectious Neuroimmune Syndromes Across the Lifespan
Dr. Carolyn Mukai, ND, Dr. Lynn Klassen, ND, Dr. Ece Toprak, ND Expanding recognition of infection-triggered neuroinflammation in children, adolescents, and adults—and the evolving role of integrative immune regulation. Abstract: This clinical commentary...
From Wheelchair to Garden: Restoring Function in Complex Post-Infectious Illness Through Foundational Naturopathic Care
Dr. Jenny Tufenkian, ND A phased naturopathic approach addressing foundational digestive stabilization, EBV reactivation, neuroinflammation, and autonomic dysfunction in a severely disabled patient. Abstract Background: Myalgic encephalomyelitis/chronic fatigue...
Mind, Immunity & Male Fertility: A Psychoneuroimmunological View of Male Reproductive Health
Dr. Nicole Cain Exploring how chronic stress, inflammation, and the gut-brain-hormone connection influence sperm quality—and how integrative, mind-body interventions can restore reproductive vitality in men. Abstract This article examines male infertility...
Targeting Mitochondrial Function for Upstream Steroidogenesis and Adrenal Health
Chris D. Meletis, N.D. A clinical framework for restoring adrenal and gonadal hormone balance by supporting mitochondrial bioenergetics, antioxidant capacity, and adaptogenic stress resilience—upstream of testosterone, cortisol, and thyroid therapies. Abstract...
Recognizing Paternal Postpartum Depression: An Underaddressed Component of Perinatal Mental Health
Alexsia Priolo Understanding the signs, risk factors, screening tools, and family-wide impacts of paternal postpartum depression—and how clinicians can better support fathers throughout the perinatal period. Abstract This article highlights paternal postpartum...
The Gut-Heart-Prostate Connection: The Link between Intestinal, Cardiovascular, and Prostate Health in Men
Lina Mockus, ND Emerging research reveals that gut-derived inflammation, microbial metabolites, and metabolic dysfunction link intestinal health to cardiovascular disease and prostate disorders—highlighting key opportunities for naturopathic, lifestyle, and...
Men’s Health & Compounding: A Pharmacist’s Perspective
Dr. Fatimah Hamade, PharmD Understanding Male Hypogonadism, Hormone Balancing, and the Role of Personalized Compounding in Optimizing Testosterone Therapy Abstract This article reviews the clinical foundations of male hypogonadism, testosterone evaluation, and...
The Most EXTREME Prostate Cancer Case I Have Seen in 23 Years of Practice…and What I Learned
Phranq D. Tamburri, NMD Abstract: A rare Gleason 10 prostate cancer in an 80‑year‑old veteran with a persistently low PSA challenges conventional risk models, highlights the limits of PSA‑based screening, and illustrates how active surveillance, patient personality,...
Georgia State Brain Researchers Draw Cellular Blueprint for How We Think, Feel
A new study from experts with Georgia State University has achieved a long-standing goal in neuroscience: showing how the brain’s smallest components build the systems that shape thought, emotion and behavior, by demonstrating how specific cell types, chemical...
The Quiet Surge in Demand for Psychiatric Drug Tapering
Razi Ann Berry, Publisher We Became a Medicated Society More than one in ten American adults now take prescription medication for depression. Women receive these prescriptions at double the rate of men. Add in antipsychotics, stimulants, mood stabilizers, and...
Metagenics Names Patrick Sly as CEO to Lead Next Chapter of Growth
Aliso Viejo, CA – December 1, 2025 Metagenics, a leading doctor-recommended professional supplement announced it has named Patrick Sly as CEO, effective immediately. A highly regarded executive in the health and wellness industry, Mr. Sly brings a wealth of...
AHPA Leads Legislative Response to Protect Herbal Tinctures in New Hampshire
The American Herbal Products Association (AHPA) is leading a coordinated industry response to protect the sale of alcohol-based herbal tinctures and liquid extracts in New Hampshire. The issue began when a concerned AHPA member reported that the New Hampshire Liquor...
The Most EXTREME Prostate Cancer Case I Have Seen in 23 Years of Practice…and What I Learned
Phranq D. Tamburri, NMD Abstract: A rare Gleason 10 prostate cancer in an 80‑year‑old veteran with a persistently low PSA challenges conventional risk models, highlights the limits of PSA‑based screening, and illustrates how active surveillance, patient personality,...
Georgia State Brain Researchers Draw Cellular Blueprint for How We Think, Feel
A new study from experts with Georgia State University has achieved a long-standing goal in neuroscience: showing how the brain’s smallest components build the systems that shape thought, emotion and behavior, by demonstrating how specific cell types, chemical...
The Quiet Surge in Demand for Psychiatric Drug Tapering
Razi Ann Berry, Publisher We Became a Medicated Society More than one in ten American adults now take prescription medication for depression. Women receive these prescriptions at double the rate of men. Add in antipsychotics, stimulants, mood stabilizers, and...
Metagenics Names Patrick Sly as CEO to Lead Next Chapter of Growth
Aliso Viejo, CA – December 1, 2025 Metagenics, a leading doctor-recommended professional supplement announced it has named Patrick Sly as CEO, effective immediately. A highly regarded executive in the health and wellness industry, Mr. Sly brings a wealth of...
AHPA Leads Legislative Response to Protect Herbal Tinctures in New Hampshire
The American Herbal Products Association (AHPA) is leading a coordinated industry response to protect the sale of alcohol-based herbal tinctures and liquid extracts in New Hampshire. The issue began when a concerned AHPA member reported that the New Hampshire Liquor...
Brazilian Copper Chelation Study Puts Numbers Behind What We’ve Been Testing For
A new compound reduced hippocampal inflammation and improved memory in Alzheimer's model rats A research team in Brazil has published animal data showing a copper chelating compound can cross the blood brain barrier, pull copper out of beta amyloid plaques, and...
A Publisher’s Warning: The Pediatric Cases That Cross My Desk 20 Years Later
Razi Ann Berry, Publisher When we started publishing cases in the Journal of Applied Naturopathic Medicine (formerly NDNR), the bulk of pediatric cases were mild: ear infections, upper respiratory infections, rashes, food allergies. Parents who brought their...
Gentle
Razi Ann Berry, Publisher Why Starting Gentle Is Actually Radical The order you do things matters. When baking bread, repairing an engine, building a house; do it out of order and it fails. In medicine, we’ve reversed the order. We start with the strongest...
Three pigs
Razi Ann Berry, Publisher Before medicine had metrics, it had stories built on observation that carried clinical truths in plain words. One of them still teaches a rule of clinical success. Build foundations, then treat. The Three Little Pigs understood the...
Your n=1 study doesn’t count.
Razi Ann Berry, Publisher After 20 years publishing NDNR monthly, I've heard this dismissal of case reports countless times. But I've come to believe we're overlooking something critical: Medicine has always been built on careful observation of individual...
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Featured News
Fluoxetine During Development Damaged Hearing and the Brainstem
ARCADIA TALLMAN Fluoxetine exposure during early auditory development drove 91 gene expression changes in the brainstem, reduced the stability of mature neural circuits, and left lasting hair-cell damage in the inner ear. Fluoxetine Changed the Developing Auditory...
Functional Longevity Summit 2026 Sets Stage for Next Wave in Precision and Regenerative Medicine
Phoenix, Arizona — Healthcare practitioners across naturopathic, functional, regenerative, and precision medicine are gearing up for one of the most comprehensive clinical education events of the year. The 2026 Functional Longevity Summit, hosted in Phoenix from...
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