Are Autism Blood and Urine Tests Coming Soon?

 In Naturopathic News

Node Smith, ND

The rates of autism in children has skyrocketed in the last few decades. Thousands of children are diagnosed with various degrees of autism, or placed on the “autism spectrum,” each year. It is estimated that as many as 1 in 68 children in the United States falls within the diagnostic criteria of autism. These diagnoses are primarily based on the behavior of a child, and their responses to behavioral assessments and tests. To date, there is no blood or urine test which is utilized to diagnose autism. But there could be soon.

Researchers Have Begun to Develop a Test

A team of researchers from the University of Warwick and the University of Bologna have begun to develop such a test.1 They noticed that children with autism have a higher level of a protein damage compared to healthy children. The time when this test would be used as a routine screening tool may be far off, yet it is worthwhile to note this direction in autism diagnosis. Because autism can be difficult to diagnose, a test such as this could be beneficial to ruling out false diagnoses and helping children get the care they need to potentially recover from a treatable condition.

The Study

The study analyzed chemical differences between 38 autistic children and 31 children without autism in both blood and urine. The ages of the children were between 5 and 12 years. Children with autism showed a general trend of having higher levels of protein damage in blood plasma. The protein damage revealed higher amounts of dityrosine and advanced glycation end products (AGEs). Dityrosine has been referred to as an “oxidation marker.” The theory thus far is that these damaged elements could be part of the cause for the development of autism. Testing for these in the future could help detect autism much earlier. Of course, the studies have not been validated in larger populations, and no samples were analyzed from children younger than 5.


  1. Anwar A, Abruzzo PM, Pasha S, et al.  Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism – a source of biomarkers for clinical diagnosis. Molecular Autism Brain, Cognition and Behavior. 2018,9:3.
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Node Smith, ND, is a naturopathic physician in Portland, OR and associate editor for NDNR. He has been instrumental in maintaining a firm connection to the philosophy and heritage of naturopathic medicine among the next generation of docs. He helped found the first multi-generational experiential retreat, which brings elders, alumni, and students together for a weekend camp-out where naturopathic medicine and medical philosophy are experienced in nature. Four years ago he helped found the non-profit, Association for Naturopathic ReVitalization (ANR), for which he serves as the board chairman. ANR has a mission to inspire health practitioners to embody the naturopathic principles through experiential education. Node also has a firm belief that the next era of naturopathic medicine will see a resurgence of in-patient facilities which use fasting, earthing, hydrotherapy and homeopathy to bring people back from chronic diseases of modern living; he is involved in numerous conversations and projects to bring about this vision.

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