Manipulating Motivation in the Brain

 In Naturopathic News


From Cold Spring Harbor Laboratory- A characteristic of depression is a lack of motivation. Cold Spring Harbor Laboratory (CSHL) Professor Bo Li, in collaboration with CSHL Adjunct Professor Z. Josh Huang, discovered a group of neurons in the mouse brain that influences the animal’s motivation to perform tasks for rewards. Dialing up the activity of these neurons makes a mouse work faster or more vigorously — up to a point. These neurons have a feature that prevents the mouse from becoming addicted to the reward. The findings may point to new therapeutic strategies for treating mental illnesses like depression that affect motivation in humans.

The anterior insular cortex is a region of the brain that plays a critical role in motivation. A set of neurons that activate a gene called Fezf2(Fezf2 neurons) in this area are active when mice are doing both physical and cognitive tasks. Li and his lab hypothesized that these neurons do not affect the mouse’s ability to do the task; rather, the brain cells influence the mouse’s motivational drive.

Mice were trained to lick a water bottle spout to receive a small sugar reward. When researchers dialed up the activity of these Fezf2 neurons, mice would lick more vigorously. If the neuron activity was dialed down, the mice would lick more slowly. The researchers saw a similar result in another experiment in which the mice ran on a wheel to receive a reward. The mice ran faster if the Fezf2 neurons were stimulated. The same effect occurred with other tasks.

Li and his team were surprised to discover a feature that prevents the mice from becoming addicted to the tasks and their rewards. When mice drank their fill of sugar water and were satiated, they would not lick or run faster to get more sugar, even if the researchers dialed up the activity of the Fezf2 neurons.

Finding a way to fine-tune the human equivalent of these neurons might help people struggling with motivation due to mental illnesses like depression. Li says, “We want to selectively increase the motivation of the person so that they can do the things that they need to do, but we don’t want to create addictive drugs.”

1. Hanfei Deng, Xiong Xiao, Tao Yang, Kimberly Ritola, Adam Hantman, Yulong Li, Z. Josh Huang, Bo Li. A genetically defined insula-brainstem circuit selectively controls motivational vigor. Cell, 2021; DOI: 10.1016/j.cell.2021.11.019

Node Smith, ND is a naturopathic physician in Humboldt, Saskatchewan and associate editor and continuing education director for NDNR. His mission is serving relationships that support the process of transformation, and that ultimately lead to healthier people, businesses and communities. His primary therapeutic tools include counselling, homeopathy, diet and the use of cold water combined with exercise. Node considers health to be a reflection of the relationships a person or a business has with themselves, with God and with those around them. In order to cure disease and to heal, these relationships must be specifically considered. Node has worked intimately with many groups and organizations within the naturopathic profession, and helped found the non-profit, Association for Naturopathic Revitalization (ANR), which works to promote and facilitate experiential education in vitalism.

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