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Low Testosterone and Cardiovascular Disease: Risk Marker, Mediator, or Both?
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Table of Contents | 2026
When Pain Was Where Shame Lived: Abdominal Pain and the Mind-Body Connection
After imaging failed to reveal a significant structural explanation for severe recurrent abdominal pain, attention shifted toward chronic stress, body image, and the mind-body connection. This case explores the patient’s experience with craniosacral therapy and integrative care as her relationship with her body changed and her abdominal pain ultimately resolved.
Medication-Induced Kidney Injury: Mechanisms, Risk Factors, and Prevention
Medications may account for an estimated 20% of community- and hospital-acquired acute kidney injury, with risk amplified by CKD, older age, chronic disease, dehydration, and polypharmacy. This review examines the major mechanisms of drug-induced nephrotoxicity and practical strategies for medication review, hydration, renal monitoring, and prevention.
Low Testosterone and Cardiovascular Disease: Risk Marker, Mediator, or Both?
Low testosterone is consistently associated with adverse cardiovascular outcomes, but whether it is a cause of vascular disease or a marker of underlying metabolic and inflammatory dysfunction remains unresolved. This review examines the epidemiology, vascular mechanisms, hypertension and atherosclerosis data, TRAVERSE findings, and the cardiovascular implications of TRT-induced erythrocytosis.
East Meets West: A Springtime Approach to Liver Detoxification
Dr. Heather Tynan, ND, DACM, Lac Abstract Bridging Traditional Chinese Medicine and Western physiology to support liver function, detoxification pathways, and systemic balance during the spring season. This article explores a seasonal, integrative approach to...
A Naturopathic Detox from the COVID Era: Healing the Profession Through Truth and Compassion
Charley Cropley, N.D Abstract A reflective exploration of professional conflict within naturopathic medicine and a vitalist framework for restoring integrity, dialogue, and collective healing. This commentary examines the impact of the COVID era on the...
Why Naturopathic Doctors Recommend Different Treatments: Understanding Individualized Care in Naturopathic Medicine
Dr. Eli Camp, ND How vitalist principles, clinical judgment, and therapeutic order shape personalized treatment strategies for the same diagnosis. Abstract This article explains why two naturopathic doctors may recommend different treatments for the same...
Curcumin Benefits and Bioavailability: Separating Mechanism from Marketing
Devin Miles, ND Abstract This article reviews the clinical evidence supporting curcumin’s role in inflammation, joint health, and oxidative stress, including comparisons with conventional therapies such as NSAIDs. It also examines the challenges of curcumin...
GLP-1 Agonists and Persistent Organic Pollutants (POPs): Lipophilic Toxin Mobilization During Rapid Fat Loss
Michael E. McEvoy, Kareem Kandil, ND This article examines the potential for rapid fat loss induced by GLP-1 agonist therapies to mobilize stored lipophilic persistent organic pollutants (POPs) from adipose tissue into circulation. It reviews evidence from weight loss...
Epstein–Barr Virus (EBV) as a Contributor to Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Dr. Todd Maderis, ND Exploring immune dysregulation, viral reactivation, mitochondrial impairment, and treatment implications in post-EBV fatigue syndromes. Abstract This article examines the role of Epstein–Barr virus (EBV) reactivation and immune exhaustion in the...
Intravenous Phosphatidylcholine in Severe Refractory Mast Cell Activation Syndrome: A Case Report
Melanie Stein, ND Clinical improvement in treatment-refractory MCAS with normal conventional biomarkers and profound oral intolerance through membrane lipid therapy. This case report describes a 34-year-old woman with severe, treatment-refractory mast cell...
PANS, PANDAS, and the Expanding Landscape of Post-Infectious Neuroimmune Syndromes Across the Lifespan
Dr. Carolyn Mukai, ND, Dr. Lynn Klassen, ND, Dr. Ece Toprak, ND Expanding recognition of infection-triggered neuroinflammation in children, adolescents, and adults—and the evolving role of integrative immune regulation. Abstract: This clinical commentary...
From Wheelchair to Garden: Restoring Function in Complex Post-Infectious Illness Through Foundational Naturopathic Care
Dr. Jenny Tufenkian, ND A phased naturopathic approach addressing foundational digestive stabilization, EBV reactivation, neuroinflammation, and autonomic dysfunction in a severely disabled patient. Abstract Background: Myalgic encephalomyelitis/chronic fatigue...
A Case of Recurring Acute Viral Meningitis
Deborah Frances RN, ND A 14-year journey from “unexplained headaches” to confirmed HSV-2 meningitis, highlighting how accurate diagnosis, antiviral botanicals, and individualized homeopathic prescribing can control severe neurologic symptoms and cardiac...
Resolution of Chronic Fatigue in a Patient With Post-COVID EBV Reactivation and Mold-Related Illness
Dr. Kasey Holland Hamski, ND A case illustrating the interplay between EBV reactivation, environmental mold exposure, and immune dysregulation in a patient with persistent post-viral fatigue. This case report examines chronic fatigue in a 38-year-old patient with...
Post-Pandemic Clinical Medicine – Addressing Long-COVID and Vaccine Injuries
An evidence-informed, dysfunction-based approach to evaluating spike protein effects, comorbidities, coagulation abnormalities, immune dysregulation, and mitochondrial dysfunction. Paul S. Anderson, NMD Abstract This clinical update summarizes a structured framework...
Integrative Management of Postural Orthostatic Tachycardia Syndrome (POTS) Following COVID-19: A Case-Based, Longitudinal Approach
Dr. Adelena Izold, ND A systems-based framework addressing autonomic dysfunction, gut–brain signaling, endocrine balance, and metabolic resilience in post-viral dysautonomia. This case report describes the integrative management of a 36-year-old female with post-viral...
Rebuilding the Brain in Chronic Fatigue Syndrome (CFS/ME): A Layered Naturopathic Approach to Neuroinflammation and Mitochondrial Dysfunction
Dr. Vy Simeles, ND, Restorative Health Clinic A case report demonstrating sequential neurorepair, lipid repletion, microbiome stabilization, and mitochondrial support in post-infectious CFS/ME recovery. Abstract This case report details the recovery of a...
Infection, Neuroinflammation, and Immune Dysregulation: The Clinical Overlap of Lyme Disease and PANS/PANDAS and a Path to Healing
Understanding the clinical overlap between vector-borne infections and pediatric acute-onset neuropsychiatric syndromes—and a systems-based integrative path to healing. Dr. Myriah Hinchey, ND, FMAPS Abstract This article examines the biological overlap between Lyme...
Archived Case Studies and Featured Content
Male Infertility and Pain Medication: When Analgesic Exposure Becomes a Fertility Clue
Could overlooked pain-medication use provide an important clue in male infertility? This case follows a 40-year-old man with oligoasthenoteratozoospermia whose total motile sperm count increased from 2.72 million to 26.5 million over 111 days following analgesic discontinuation and a multicomponent integrative fertility plan.
Cardiovascular Risk Assessment in Men: A Naturopathic Cardiology Perspective
Cardiovascular risk extends beyond LDL cholesterol and the standard lipid panel. This review explores how plaque biology, inflammation, oxidation, metabolic and hormonal health, advanced biomarkers, CGM, and cardiovascular imaging can complement established therapies to create a more individualized approach to cardiovascular risk assessment in men.
The Role of Hormonal Changes in the Etiology and Treatment of Paternal Perinatal Mood and Anxiety Disorders
Approximately 1 in 10 fathers experience a perinatal mood or anxiety disorder, yet paternal PMADs remain frequently overlooked. This review explores the hormonal and psychosocial changes accompanying fatherhood and their implications for recognizing, screening, and supporting paternal mental health.
Oral Curcumin and Artesunate Protocol in Prostatic Carcinoma: Case Study Series in PSA and Pathology Outcomes
Can curcumin and artesunate play a role in integrative prostate cancer care? This two-patient case series examines PSA trajectories and pathology during an oral botanical protocol incorporating curcumin and artesunate, while highlighting potential mechanisms, iron-related adverse effects, and the need for further clinical investigation.
From PCOS to PMOS: What the Name Change Means for Your Practice
Dr. Jaclyn Smeaton, ND A clinical review of the landmark renaming of PCOS to PMOS and why this shift reframes the condition as a whole-body endocrine and metabolic disorder requiring broader assessment and long-term care. This article explores the recent...
Collaborative Fertility Care: How Naturopathic Doctors and Nurse Practitioners Can Expand Integrative Treatment Options
Dr. Nora Pope ND, FCP A clinical exploration of how collaborative ND–NP care can bridge prescribing limitations, integrate restorative fertility strategies, and expand access to individualized reproductive treatment. This article examines the clinical value of...
Resolving Fatigue, Food Sensitivities, and PMS in a 38-Year-Old Female: A Gut–HPA Axis Case Report
Dr. Brian Lamoreux, ND, MA, LPCC A clinical case exploring the interconnected roles of HPA axis dysfunction, gut dysbiosis, food reactivity, and stress physiology in new-onset fatigue and premenstrual symptoms. This case report follows a 38-year-old woman with...
Progesterone Resistance and Implantation Failure: An Integrative Approach to Endometrial Receptivity
Dr. BreAnna Guan, ND A whole-person exploration of how inflammation, endocrine disruptors, metabolic dysfunction, gut dysbiosis, and stress may impair progesterone signaling and compromise fertility. This article examines progesterone resistance as an...
Age-Related Fertility Decline: Improving Oocyte Quality Through Integrative Naturopathic Care
Dr. Shannon Sinsheimer, ND A clinical review of mitochondrial dysfunction, oxidative stress, and evidence-informed nutritional strategies to support oocyte maturation, embryo quality, and successful conception in advanced reproductive age. This article explores...
Restoration of Cycle Regularity and Healthy Pregnancy in a 41-Year-Old Woman with Diminished Ovarian Reserve: A Naturopathic Case Report
Dr. Aumatma Simmons, ND A root-cause fertility case exploring hormonal optimization, vaginal microbiome restoration, luteal phase support, and individualized naturopathic care in advanced reproductive age. This case report details the successful restoration of...
Natural Conception Following Ovarian PRP and Integrative Naturopathic Fertility Care: Two Case Reports
Dr. Emmalyn Pratt, ND Two fertility case reports exploring the potential role of ovarian platelet-rich plasma (PRP) alongside naturopathic interventions in women with diminished ovarian reserve, recurrent pregnancy loss, and failed assisted reproductive...
From Protocols to Precision: Using Organic Acid Testing to Personalize IVF Preparation
Dr. Shannon Iselin, ND How metabolomic assessment of oxidative stress, mitochondrial function, and nutrient sufficiency may help optimize reproductive outcomes beyond conventional fertility markers. This article explores the potential role of organic acid...
NWHSU Launches New Doctor of Clinical Nutrition in Functional & Integrative Nutrition
Northwestern Health Sciences University (NWHSU) is proud to announce the launch of its new Doctor of Clinical Nutrition (DCN) in Functional and Integrative Nutrition– a practice-focused doctoral degree designed for nutrition and healthcare professionals ready to...
Rethinking Mental Health Treatment: The Clinical Case for Natural Neurotransmitter Support
Dr. Jaquel Patterson, ND, Dr. Elizabeth Sutherland, ND, and Dr. Devin Miles, ND A clinical review of evidence-based botanical and nutritional compounds that support serotonergic, dopaminergic, GABAergic, and stress-response pathways in...
Restoration of Cycle Regularity and Healthy Pregnancy in a 41-Year-Old Woman with Diminished Ovarian Reserve: A Naturopathic Case Report
Dr. Aumatma Simmons, ND A root-cause fertility case exploring hormonal optimization, vaginal microbiome restoration, luteal phase support, and individualized naturopathic care in advanced reproductive age. This case report details the successful restoration of...
Natural Conception Following Ovarian PRP and Integrative Naturopathic Fertility Care: Two Case Reports
Dr. Emmalyn Pratt, ND Two fertility case reports exploring the potential role of ovarian platelet-rich plasma (PRP) alongside naturopathic interventions in women with diminished ovarian reserve, recurrent pregnancy loss, and failed assisted reproductive...
From Protocols to Precision: Using Organic Acid Testing to Personalize IVF Preparation
Dr. Shannon Iselin, ND How metabolomic assessment of oxidative stress, mitochondrial function, and nutrient sufficiency may help optimize reproductive outcomes beyond conventional fertility markers. This article explores the potential role of organic acid...
NWHSU Launches New Doctor of Clinical Nutrition in Functional & Integrative Nutrition
Northwestern Health Sciences University (NWHSU) is proud to announce the launch of its new Doctor of Clinical Nutrition (DCN) in Functional and Integrative Nutrition– a practice-focused doctoral degree designed for nutrition and healthcare professionals ready to...
Rethinking Mental Health Treatment: The Clinical Case for Natural Neurotransmitter Support
Dr. Jaquel Patterson, ND, Dr. Elizabeth Sutherland, ND, and Dr. Devin Miles, ND A clinical review of evidence-based botanical and nutritional compounds that support serotonergic, dopaminergic, GABAergic, and stress-response pathways in...
Ovulation-Triggered Migraine: A Naturopathic Clinical Case Study
By Majid Michael Sababi, ND, DC, MS, MUAc, ABDA A 38-year-old female with predictable mid-cycle and late luteal migraines achieved relief through an integrative approach combining nutrition, botanicals, supplementation, and conventional care. This case study...
Mediterranean Diet and Olive Oil in Women’s Health: Clinical Evidence and Applications
By Dr. Artemis Morris, ND From ancestral kitchen wisdom to modern research, exploring how the Mediterranean diet supports hormonal health, fertility, pregnancy, menopause, and longevity. This article examines the Mediterranean diet as a clinically validated,...
Lactational Mastitis: Naturopathic and Integrative Treatment Protocols
by Dr. Daniella Perri, ND Understanding the causes, symptoms, and evidence-based conventional and alternative therapies — including probiotics, allicin, and therapeutic ultrasound — to support recovery and prevent recurrence. This article explores the...
Naturopathic Dementia Prevention: Clinical Strategies for Neurodegeneration
Dr. Majid Michael Sababi, ND, DC, MS, MUAc, ABDA A practical framework addressing injury load, neuroplastic repair, and multi-domain interventions including lifestyle, diet, sleep, stress, and targeted nutraceutical strategies. This article presents a...
Estrogen Metabolism and the Gut Microbiome: Clinical Strategies for Hormone Detoxification
Dr. Holly Lucille, RN, ND A comprehensive review of liver detoxification phases, the estrobolome, and lifestyle, nutritional, and botanical strategies to support healthy estrogen balance. This article explores estrogen metabolism through a whole-person lens,...
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