Adrianne M. Cook, ND, FABNE A case report illustrating how fatigue, weight gain, brain fog, metabolic dysfunction, and vasomotor symptoms initially attributed to menopause revealed underlying hypopituitarism, central adrenal insufficiency, and secondary...

Trending Articles
Relative Energy Deficiency in Sport (RED-S): When “Eat Less, Move More” Backfires in Active Adults
Ben Alter, MA, ND How chronic low energy availability disrupts metabolism, hormones, recovery, immune function, and performance—and why recreationally active individuals may be especially vulnerable. This article explores Relative Energy Deficiency in Sport (RED-S), a...
Vitamin D Beyond Bone Health: Emerging Roles in Immunity, Metabolic Health, PMOS, and Disease Prevention
Dr. Daniella Perri, ND From widespread deficiency to VDR signaling across tissues, this review synthesizes evidence on how vitamin D shapes immunity, infection severity (including COVID-19), tumor biology, uterine fibroids, metabolic syndrome, and PMOS—and outlines...
Liver-Centered Model of Midline Adiposity & MASLD
by Majid Michael Sababi, ND, DC, MS, MUAc, ABDA Discover how hepatic steatosis, insulin resistance, and liver dysfunction contribute to visceral fat accumulation, and explore evidence-informed assessment and treatment strategies that integrate modern hepatology with...
Recurrent Pregnancy Loss Assessment: An Integrative Approach
Dr. Juline Savaya, ND Beyond “Unexplained” Recurrent Pregnancy Loss: An Integrative Approach to Immune, Hormonal, Thrombophilic, and Male-Factor Assessment Pregnancy loss occurs in approximately 15% to 20% of recognized pregnancies, though the true prevalence...
Featured Article | Insomnia/Sleep Medicine
A Root-Cause Approach to Menopausal Insomnia and Brain Dysfunction: A Case Study
Discover how a 48-year-old woman overcame chronic insomnia, fatigue, and cognitive decline during menopause through a personalized, brain-first, hormone-balancing approach. Stephanie Yang, ND Abstract Menopause is not only a hormonal milestone but also a neurological...
Exclusive Content | Insomnia/Sleep Medicine
The ECS, Cannabis, & Sleep
JAKE F. FELICE, ND, LMP Sleep is a dynamic and essential activity that involves a multitude of physiologic processes. Proper sleep assists the body with tissue repair, immune maintenance, memory storage, appetite, blood sugar control, blood...
Insomnia, Substance Use, & Anxiety: Looking to the Therapeutic Order to Restore Balance
Student Scholarship – 3rd Place Case Study Lana FerrisJennifer Brusewitz, ND As naturopathic physicians, we understand that quality sleep is foundational to our patients’ well-being. Many patients suffer from comorbid conditions that interfere with...
Notes from the Field: December, 2019
Nature Cure Clinical Pearls Jared L. Zeff, ND, VNMI, LAc The following is a not an article prepared for a medical journal. Not every statement of fact is cited or referenced. This is a commentary on the medicine, a running set of observations about practice in the...
Dialing Up the Vis, Part 3
The Vital Conversation James Sensenig, ND This is the third part of a 3-part article from The Vital Conversation that took place on June 22, 2016. It is part of a new series of articles in NDNR that is based on transcripts of conversations that occurred on Wednesdays...
Public Sector Higher Ed: Slippery Slope or the Next Best Path?
Education David J. Schleich, PhD We’ve been sparring with the biomedicine industry all along the professional formation continuum (education, research, licensing) for a very long time. We have also been joining some aspects of the mainstream’s strategies for a...
Platelet-Rich Plasma (PRP)
Regenerative Medicine Fred G. Arnold, DC, NMD Platelet-Rich Plasma (PRP) is the third topic in my series about regenerative medicine treatments for painful musculoskeletal conditions. This regenerative injection procedure was originally used in 1987 following...
Fatigue Due to Mold Exposure: Pathophysiology
Tolle Causam Lauren Tessier, ND Illness resulting from mold and mycotoxin exposure is gaining more traction and attention. As the paradigm shift occurs, mold and mycotoxin-induced illness (MMII) should be brought to the forefront of clinical education, both in school...
Kratom: Miracle Herb or Public Health Danger?
Naturopathic Perspective Saul Marcus, ND Mitragyna speciosa (common name, kratom) is an herb from Southeast Asia. Traditionally, it has been used by workers to help them have more stamina during long workdays. A tea would be brewed from leaves, and consumed throughout...
Archived Case Studies and Featured Content
ClarityTx Launches Clinical Decision-Support Platform for Integrative Medicine
ClarityTx, a healthcare technology company, announced the launch of its clinical decision-support platform designed specifically for integrative and functional medicine practitioners. Created by a multidisciplinary team of clinicians, the platform helps practitioners...
Fibromyalgia and Chronic Fatigue Syndrome: A Mitochondrial Perspective on Recovery and Root Causes
Wiet van Helmond, Classical Homeopath Drawing from decades of clinical experience and a representative case study, this article explores how mitochondrial dysfunction, chronic inflammation, post-viral illness, psychosocial stress, and individualized homeopathic...
Brain Death Reconsidered Brain Death Reconsidered: Examining the Medical, Legal, and Ethical Debate Over Organ Donation
Heidi Klessig MD This commentary explores ongoing debates surrounding the concept of brain death, reviewing historical definitions, legal standards, published case reports, and ethical questions regarding informed consent and organ donation. Is brain death...
Root-Cause Diabetes Prevention: A Naturopathic Approach to Insulin Resistance and Metabolic Health
Jack Duke, ND Type 2 diabetes develops over years of progressive metabolic dysfunction. This article reviews the pathophysiology of insulin resistance, highlights strategies for early detection, and presents practice-based outcomes from a 12-week naturopathic...
Collaborative Fertility Care: How Naturopathic Doctors and Nurse Practitioners Can Expand Integrative Treatment Options
Dr. Nora Pope ND, FCP A clinical exploration of how collaborative ND–NP care can bridge prescribing limitations, integrate restorative fertility strategies, and expand access to individualized reproductive treatment. This article examines the clinical value of...
Resolving Fatigue, Food Sensitivities, and PMS in a 38-Year-Old Female: A Gut–HPA Axis Case Report
Dr. Brian Lamoreux, ND, MA, LPCC A clinical case exploring the interconnected roles of HPA axis dysfunction, gut dysbiosis, food reactivity, and stress physiology in new-onset fatigue and premenstrual symptoms. This case report follows a 38-year-old woman with...
Progesterone Resistance and Implantation Failure: An Integrative Approach to Endometrial Receptivity
Dr. BreAnna Guan, ND A whole-person exploration of how inflammation, endocrine disruptors, metabolic dysfunction, gut dysbiosis, and stress may impair progesterone signaling and compromise fertility. This article examines progesterone resistance as an...
Age-Related Fertility Decline: Improving Oocyte Quality Through Integrative Naturopathic Care
Dr. Shannon Sinsheimer, ND A clinical review of mitochondrial dysfunction, oxidative stress, and evidence-informed nutritional strategies to support oocyte maturation, embryo quality, and successful conception in advanced reproductive age. This article explores...
Restoration of Cycle Regularity and Healthy Pregnancy in a 41-Year-Old Woman with Diminished Ovarian Reserve: A Naturopathic Case Report
Dr. Aumatma Simmons, ND A root-cause fertility case exploring hormonal optimization, vaginal microbiome restoration, luteal phase support, and individualized naturopathic care in advanced reproductive age. This case report details the successful restoration of...
Natural Conception Following Ovarian PRP and Integrative Naturopathic Fertility Care: Two Case Reports
Dr. Emmalyn Pratt, ND Two fertility case reports exploring the potential role of ovarian platelet-rich plasma (PRP) alongside naturopathic interventions in women with diminished ovarian reserve, recurrent pregnancy loss, and failed assisted reproductive...
From Protocols to Precision: Using Organic Acid Testing to Personalize IVF Preparation
Dr. Shannon Iselin, ND How metabolomic assessment of oxidative stress, mitochondrial function, and nutrient sufficiency may help optimize reproductive outcomes beyond conventional fertility markers. This article explores the potential role of organic acid...
NWHSU Launches New Doctor of Clinical Nutrition in Functional & Integrative Nutrition
Northwestern Health Sciences University (NWHSU) is proud to announce the launch of its new Doctor of Clinical Nutrition (DCN) in Functional and Integrative Nutrition– a practice-focused doctoral degree designed for nutrition and healthcare professionals ready to...
Rethinking Mental Health Treatment: The Clinical Case for Natural Neurotransmitter Support
Dr. Jaquel Patterson, ND, Dr. Elizabeth Sutherland, ND, and Dr. Devin Miles, ND A clinical review of evidence-based botanical and nutritional compounds that support serotonergic, dopaminergic, GABAergic, and stress-response pathways in...
Ovulation-Triggered Migraine: A Naturopathic Clinical Case Study
By Majid Michael Sababi, ND, DC, MS, MUAc, ABDA A 38-year-old female with predictable mid-cycle and late luteal migraines achieved relief through an integrative approach combining nutrition, botanicals, supplementation, and conventional care. This case study...
Natural Conception Following Ovarian PRP and Integrative Naturopathic Fertility Care: Two Case Reports
Dr. Emmalyn Pratt, ND Two fertility case reports exploring the potential role of ovarian platelet-rich plasma (PRP) alongside naturopathic interventions in women with diminished ovarian reserve, recurrent pregnancy loss, and failed assisted reproductive...
From Protocols to Precision: Using Organic Acid Testing to Personalize IVF Preparation
Dr. Shannon Iselin, ND How metabolomic assessment of oxidative stress, mitochondrial function, and nutrient sufficiency may help optimize reproductive outcomes beyond conventional fertility markers. This article explores the potential role of organic acid...
NWHSU Launches New Doctor of Clinical Nutrition in Functional & Integrative Nutrition
Northwestern Health Sciences University (NWHSU) is proud to announce the launch of its new Doctor of Clinical Nutrition (DCN) in Functional and Integrative Nutrition– a practice-focused doctoral degree designed for nutrition and healthcare professionals ready to...
Rethinking Mental Health Treatment: The Clinical Case for Natural Neurotransmitter Support
Dr. Jaquel Patterson, ND, Dr. Elizabeth Sutherland, ND, and Dr. Devin Miles, ND A clinical review of evidence-based botanical and nutritional compounds that support serotonergic, dopaminergic, GABAergic, and stress-response pathways in...
Ovulation-Triggered Migraine: A Naturopathic Clinical Case Study
By Majid Michael Sababi, ND, DC, MS, MUAc, ABDA A 38-year-old female with predictable mid-cycle and late luteal migraines achieved relief through an integrative approach combining nutrition, botanicals, supplementation, and conventional care. This case study...
Mediterranean Diet and Olive Oil in Women’s Health: Clinical Evidence and Applications
By Dr. Artemis Morris, ND From ancestral kitchen wisdom to modern research, exploring how the Mediterranean diet supports hormonal health, fertility, pregnancy, menopause, and longevity. This article examines the Mediterranean diet as a clinically validated,...
Lactational Mastitis: Naturopathic and Integrative Treatment Protocols
by Dr. Daniella Perri, ND Understanding the causes, symptoms, and evidence-based conventional and alternative therapies — including probiotics, allicin, and therapeutic ultrasound — to support recovery and prevent recurrence. This article explores the...
Naturopathic Dementia Prevention: Clinical Strategies for Neurodegeneration
Dr. Majid Michael Sababi, ND, DC, MS, MUAc, ABDA A practical framework addressing injury load, neuroplastic repair, and multi-domain interventions including lifestyle, diet, sleep, stress, and targeted nutraceutical strategies. This article presents a...
Estrogen Metabolism and the Gut Microbiome: Clinical Strategies for Hormone Detoxification
Dr. Holly Lucille, RN, ND A comprehensive review of liver detoxification phases, the estrobolome, and lifestyle, nutritional, and botanical strategies to support healthy estrogen balance. This article explores estrogen metabolism through a whole-person lens,...
Integrative Treatment of Anxiety and Depression: A Clinical Case Report
by Dr. Christina Bjorndal, ND A six-year case study demonstrating the role of nutrition, lifestyle, and psychotherapeutic interventions in resolving complex mental health conditions. This case report details the successful resolution of anxiety, depression,...
Custom Publishing
Hyperbaric Oxygen Therapy in Sports Medicine: Clinical Applications in Concussion and Musculoskeletal Injury
Joseph Thomas, MD, MBA, Fellow of Metabolic and Nutritional Medicine In collaboration with Oxygen Health Systems Abstract Hyperbaric oxygen therapy has gained traction as an adjunct in sports medicine, particularly in concussion management and musculoskeletal injury....
Quantum Fields and Frequency Medicine
Quantum Fields and Frequency Medicine A Conversation with Philipp Samor von Holtzendorff Fehling on Remote Quantum Technology and Human Performance Interest in frequency medicine and subtle energy technologies continues to grow within integrative and naturopathic...
Increased Intracellular NAD+ Levels via Oral Supplementation With a Novel Liposomal Delivery Method: A Non-Randomized Crossover Study
Blair E, Miller A, McDonald R. Introduction: NAD+ is a critical coenzyme for cellular energy production, DNA repair, and sirtuin activity, with levels known to decline with age. While oral NAD+ supplementation is proposed for healthy aging benefits, its efficacy in...
Featured News
The 2026 AzureWellness Summit
Building a Community of Practitioners to Inspire Healthier Families June 22–26 Five Day Virtual Event of Education, Insight, and Whole-Person Wellness AzureWell is pleased to announce the Azure Wellness Summit, a free five-day virtual event taking place June...
NWHSU Launches New Doctor of Clinical Nutrition in Functional & Integrative Nutrition
Northwestern Health Sciences University (NWHSU) is proud to announce the launch of its new Doctor of Clinical Nutrition (DCN) in Functional and Integrative Nutrition– a practice-focused doctoral degree designed for nutrition and healthcare professionals ready to...










