Small Intestine Bacterial Overgrowth: The Case of the Perpetual Patient

Dr. Allison Siebecker, ND, LAc
Dr. Steven Sandberg-Lewis, ND, DHANP

While the concept of dysbiosis is not new, the research on Small Intestine Bacterial Overgrowth (SIBO) is.  It is showing that bacteria cause chronic constipation, an astounding finding.  We already knew pathogenic bacteria cause diarrhea, but what about normal bacteria, just overgrown in the SI?  SIBO is being hailed as the actual cause of IBS, and a major contributor to fibromyalgia (via “auto-intoxication” of bacterial endotoxins) as well as many other conditions as would be expected from any serious disturbance of SI structure or function.  Principle researcher Dr Mark Pimentel and his team at Cedars-Sinai (C-S) hospital in Los Angeles have been at the forefront of this work and have pioneered a treatment protocol (Pimentel 2006).  Our treatment combines their work with that of the late Canadian researcher Elaine Gottschall who explained SIBO without naming it such, and detailed Dr Haas’s Specific Carbohydrate Diet, in her book Breaking the Vicious Cycle.  Our approach also includes customary Naturopathic treatment.

Bacteria are normally kept at low levels in the SI (<100 thousand/mL) by bactericidal GI secretions, the migrating motor complex (MMC) which sweeps it clean between meals and at night, as well as the ileocecal valve, which prevents backflow.  Conversely the LI is meant to have a large bacterial population (100 billion/mL) where they perform helpful activities.  If the normal SI protections are compromised by factors such as acute GI infection, GI surgery, disease or chronic stress, overgrowth can and does occur.

SIBO wreaks havoc, causing mucosal damage, increased permeability, deconjugation of bile, bacterial consumption of nutrients and accumulation of bacterial acids and gas.  Common GI symptoms include bloating, abdominal pain, diarrhea, constipation (or both), heartburn and nausea.  Common systemic symptoms include food sensitivities, headache, joint pain, and respiratory, skin, brain and mood symptoms.  Malabsorption signs include steatorrhea and anemia (microcytic or macrocytic).

Consider the case of a 28 year old female who presents with chief complaints of IBS-A and chronic heartburn.  She also complains of restless legs, rosacea and sleep disturbances.  Her IBS symptoms consist of diarrhea 4-5 x day, alternating with constipation.  She describes her epigastric pain as burning over the sternum which she uses DGL for, all day long and often at night.  She uses vinegar before meals but too much aggravates the pain and doesn’t take it away, although it helps some.  She has chronic initial insomnia, night terrors and nocturia 3-4 x night.  She says “grains don’t digest for me”.  She is being treated for Hashimoto’s thyroiditis by another ND.  Labs reveal a negative H pylori breath test and chronic low ferritin.

Of particular note is the fact that this patient had worked extensively with many ND’s, holistic MD’s and acupuncturists, including elders of distinction in each field, but did not find relief.  This could only be because of missing information, since it surely wasn’t modality variety, skill or experience that was lacking.  Having studied SIBO for the previous year, we hoped we had something new to offer her.

A 3 hour lactulose breath test (see resources) was performed which revealed distal SI bacterial overgrowth.  The treatment was 3 fold: diet, antibiotics with probiotics and an SI motility agent (prokinetic).  The diet removes food that would feed bacteria, as well as foods that cannot be digested by a damaged brush border.  The antibiotic(s) are virtually non-absorbable which means they stay in the SI acting locally and don’t cause systemic side effects common to absorbable antibiotics (Pimentel 2006).  We gave her probiotics to prevent antibiotic resistance (even though it’s not supposed to happen with these drugs) and yeast overgrowth.  The use of probiotics in treating SIBO is not common MD practice, though the few studies using them show success (Cuoco 2006, Barrett 2008, Weinstock 2004).  The prokinetic stimulates the MMC to help prevent future overgrowth.  Although the prokinetic is an antibiotic, it is not used for that purpose and is very low dose (compounding necessary)( Pimentel 2009).

Treatment

  • Specific Carbohydrate Diet (SCD) ongoing
  • Klaire Ther-Biotic (25 billion multi-strain) BID ongoing
  • Rifaximin (trade name Xifaxan) 600mg BID x 7 days
  • Erythromycin 50mg HS x 90 days, started upon completion of Rifaximin

She started the SCD one week prior to meds and experienced some relief of GI symptoms.  While on Rifaximin she reported feeling lots of energy and had total and complete relief from all GI and rosacea symptoms.  At her 2 ½ month follow up she continued to have no GI pain or diarrhea but had developed constipation.  She uses magnesium to correct this.  Her skin is improved but not as completely as it was while on the antibiotic.  There is no improvement in her restless legs or sleep.  She lost 5 lbs, which was welcome.  Her ferritin level had doubled (no iron supplementation was given).  She remarked that she is “amazed”, “very pleased” and “really happy” with her results.

At 3 months her prokinetic was stopped and she elected to add gluten-free grains to her diet, and found that oats could be tolerated.  At 6 month follow up, her skin and sleep are improved and she stated that her restless legs are controlled by magnesium.  She reports she is still “doing absolutely great.”

We speculate that her constipation may have been due to a sudden decrease in fiber on her new diet, which can be increased if the patient chooses.  We are unsure of the success of the treatment for her restless legs, since she has not stopped Mg to observe symptoms without it, but excellent results have been shown in the literature for restless legs by treating SIBO (Weinstock 2008).  Current dosages of antibiotics are more effective then the dosage used in this case (Scarpellini 2007, Low 2010).  A possible reason for the remaining residual symptoms could be that bacterial elimination was insufficient at the end of her antibiotic course (re-testing was not performed).

We find that we are just as pleased with the result as the patient is.  The incredible new advances in this old field have offered us much needed solutions and understanding.  We hope to encourage the consideration of SIBO diagnosis and treatment, not only for previously irresolvable ‘perpetual patients’ but for those with any GI disorder, systemic disorders of ‘leaky gut’ origin and any illness where dysbiosis is suspected.

  • Current C-S Antibiotic Doses (Pimentel 2010)
  • For diarrhea symptoms (incl alt/constipation): Rifaximin 550mg TID x 10 days
  • For constipation symptoms: Rifaximin 550mg TID x 10 days & Neomycin 500 mg BID x 10 days

Dr Allison Siebecker

Dr Allison Siebecker

Dr. Allison Siebecker, ND, MSOM, LAc, is a 2005 graduate of The National College of Naturopathic Medicine where she earned both her Naturopathic Doctorate and her Masters in Oriental Medicine. She has a 22-year career in the nutritional field. She received the Best in Naturopathy award from the Townsend Letter for her 2005 article “Traditional Bone Broth in Modern Health and Disease.” Dr. Siebecker specializes in treating SIBO at the NCNM clinic in Portland Or and is writing a book on small intestine bacterial overgrowth, synthesizing all the data into one comprehensive source.

 Dr Steven Sandberg-Lewis

Dr Steven Sandberg-Lewis

Dr. Sandberg-Lewis, ND, DHANP, has been a practicing naturopathic physician since his graduation from National University of Natural Medicine (NUNM) in 1978. He has been a professor at NUNM since 1985, teaching a variety of courses but primarily focusing on gastroenterology and GI physical medicine. His clinic rotations are particularly popular among NUNM doctoral students. In addition to supervising clinical rotations he also maintains a part-time practice at 8Hearts Health and Wellness in Portland, Oregon.

He is a popular international lecturer at functional medicine seminars, presents webinars, writes articles for NDNR and the Townsend Letter and is frequently interviewed on issues of digestive health and disease. He is the author of the medical textbook Functional Gastroenterology: Assessing and Addressing the Causes of Functional Digestive Disorders, Second Edition, 2017, which is available at amazon.com. In 2010 he co-founded the SIBO Center at NUNM which is one of only four centers in the USA for Small Intestine Bacterial Overgrowth diagnosis, treatment, education and research. In 2014 he was named one of the “Top Docs” in Portland monthly magazine’s yearly healthcare issue and in 2015 was inducted into the OANP/NUNM Hall of Fame.

Within gastroenterology, he has special interest and expertise in inflammatory bowel disease (including microscopic colitis), irritable bowel syndrome (including post-infectious IBS), Small Intestine Bacterial Overgrowth (SIBO), hiatal hernia, gastroesophageal and bile reflux (GERD), biliary dyskinesia, and chronic states of nausea and vomiting.

Many of the patients referred to Dr. Sandberg-Lewis have digestive conditions that have defied diagnosis and effective resolution. Often these patients desire naturopathic treatment options in lieu of the courses of treatments they have previously undergone. He understands diseases of the gastrointestinal tract, but also can assess function and often find successful treatments to regain a balance in the digestive system.

Dr. Sandberg-Lewis lives in Portland with his wife, Kayle. His interests include mandolin, guitar and voice; cross country skiing; writing and lecturing.


References

Pimentel, Mark. A New IBS Solution. Sherman Oaks, Ca, Health Point Press, 2006.

Cuoco L, Salvagnini M. Small intestine bacterial overgrowth in irritable bowel syndrome: a retrospective study with rifaximin. Minerva Gastroenterol Dietol. 2006 Mar;52(1):89-95.

Barrett JS, et al. Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome. World J Gastroenterol. 2008 Aug 28;14(32):5020-4.

Weinstock L, Fern S. Treatment of bacterial overgrowth in patients with IBS.  Best Prac Res Clin Gastro. 2004;18:773-86.

Pimentel M, et al. Low-dose nocturnal tegaserod or erythromycin delays symptom recurrence after treatment of irritable bowel syndrome based on presumed bacterial overgrowth. Gastroenterol Hepatol. 2009 Jun;5(6):435-42.

Weinstock LB, et al. Restless legs syndrome in patients with irritable bowel syndrome: response to small intestinal bacterial overgrowth therapy. Dig Dis Sci. 2008 May;53(5):1252-6.

Scarpellini E, et al. High dosage rifaximin for the treatment of small intestinal bacterial overgrowth. Aliment Pharmacol Ther. 2007 Apr 1;25(7):781-6.

Low K, et al. A combination of rifaximin and neomycin is most effective in treating irritable bowel syndrome patients with methane on lactulose breath test. J Clin Gastroenterol. 2010 Sep;44(8):547-50.

Pimentel, M.  Phone update of current Cedars-Sinai Protocol Antibiotic doses. Nov 2010.

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Showing 7 comments
  • Connie crutchfield
    Reply

    Thank you so much for this information. It has been most helpful.
    I would like to have updates to this information.

  • Mike
    Reply

    Sounds great, can you help me out? Tried Xifaxan® 550 mg. Seemed to help first time, symptoms came back within days. Tried a second round about a month later – no help at all. Doctors around here don’t have a clue.

    Keep up the research. Thanks.

  • Lisa
    Reply

    Specific bacterias found to cause constipation and IBS. Natural alternatives to antibiotics. 🙂
    http://cegant.com/integrative-medicine/got-constipation-part-2

  • Jane
    Reply

    Can you please explain why ferritin would increase after treating SIBO?

  • Llana
    Reply

    I’ve been diagnosed with SIBO last year. Tried herbal intimicrobials and probiotics and SIBO diet. GReatly improved, but relapsed a year later. Strict adherence to SIBO and then SCD diet is so important. This year I had my boys tested, all three of them also have SIBO. We are staying on SIBO diet for two month already. My ND prescribed ParaGuard and enzymes and diet.

  • Patti
    Reply

    I was recently diagnosed w/ SIBO and had the 10-day course of Metronidazole. Days 1 – 8 were like a miracle w/ no constipation, painful gas, bloating and misery. By day 9, all my symptoms were back. My G.I. dr. thought my reaction to antibiotics was interesting, yet Rx’d Linzess as the solution and said if my body did not get used to Linzess, a colonoscopy would be recommended (last colonoscopy was 5 yrs. ago & results were normal). Not only is the solution of constipation being ignored, but my 40 lb. unintentional weight loss has not been addressed by my G.I. dr. He’s non-supportive of a SIBO diet, so I am fumbling my way through the diet without medical support.

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  • […] Overgrowth of the small intestine with bacteria that produce endotoxins appears to have significance in both animal models and human disease. Chlamydia species as well as Borrelia burgdorferi (Lyme) can produce toxins that cause hypersensitive of pain in soft tissues in fibromyalgia and animal models of fibromyalgia. SIBO-small intestinal bacterial overgrowth- in experimental animals caused the same hypersensitivity of the soft tissues and also leaky gut syndrome. […]

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